ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012
Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06465628 (Effect of Self-administered Acupressure for Improving Xerostomia in Head and Neck Cancer Patients), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Self-administered Acupressure for Improving Xerostomia in Head and Neck Cancer Patients: a Randomized Controlled Trial
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Intensive nutritional care for patients treated with radiotherapy in head and neck cancer: a randomized study and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy.Lasers in medical science · 2017Trial
- Influence of prosthetic rehabilitation on salivary flow, pH, and comfort sensation in patients treated for head and neck cancer.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2026Article
- The impact of perioperative oral care on postoperative infection in patients with esophageal cancer: a retrospective cohort study before and during COVID-19.Surgery today · 2025Article
- A method for sensitivity analysis of automatic contouring algorithms across different contrast weightings using synthetic magnetic resonance imaging.Physics and imaging in radiation oncology · 2025Article
- A Method for Sensitivity Analysis of Automatic Contouring Algorithms Across Different MRI Contrast Weightings Using SyntheticMR.medRxiv : the preprint server for health sciences · 2025Article
- [Physical long-term consequences of cancer].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2022Review
- Quality of Life in Orthodontic Cancer Survivor Patients-A Prospective Case-Control Study.International journal of environmental research and public health · 2020Article
- Variations in odontological care routines for patients undergoing treatment for head and neck cancer in county councils/regions of Sweden.Clinical and experimental dental research · 2020Article
- [Analysis of the risk factors of radiation-induced caries in patients with head and neck cancer].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Article
- An evaluation of nutrition intervention during radiation therapy in patients with locoregionally advanced nasopharyngeal carcinoma.Oncotarget · 2017Article
- Orthodontic Therapy for Paediatric Cancer Survivors: A Review.Journal of clinical and diagnostic research : JCDR · 2017Review
- Effect of therapeutic doses of radiotherapy on the organic and inorganic contents of the deciduous enamel: an in vitro study.Clinical oral investigations · 2016Article
- HPV Associated Head and Neck Cancer.Cancers · 2016Review
- Topical application of Aloe vera and vitamin E on induced ulcers on the tongue of rats subjected to radiation: clinical and histological evaluation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Modulation of therapeutic sensitivity by human papillomavirus.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2015Review
- Proliferative Activity of Myoepithelial Cells in Irradiated Rabbit Parotid and Submandibular Salivary Glands.Journal of international oral health : JIOH · 2015Article
- Oral health in oncology: impact of immunotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors.Oral radiology · 2014Article
- Late Oral Complications Caused by Head and Neck Radiotherapy: Clinical and Laboratory Study.Journal of oral & maxillofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to assess the late oral complications and the role of salivary gland hypofunction in the severity of mucosal reaction in nonsurgical head and neck cancer patients, submitted to radiotherapy with or without chemotherapy. METHODS AND MATERIALS: Five hundred fifteen charts from patients treated between 2005 and 2009 were reviewed, and 41 patients met the inclusion criteria. Salivary gland function was assessed using a simplified grading system (GSX) and sialometry. Late effects were assessed using the Common Toxicity Criteria (CTC Version 2.0).
resultsThe average follow-up was 17.1 (4-51) months. A statistical correlation was found for whole salivary flow rates and the average CTC grades for the mucous membrane. Both unstimulated/stimulated whole salivary flow rates (<0.09 mL/min) were identified as potential risk factors (p < 0.05) and an independent predictor for late mucous membrane toxicity (≥ grade 2). A significant correlation was also found between unstimulated salivary flow rates-GSX scores (p = 0.001) and CTC grades for salivary glands. Eighty-five percent of the patients were classified as suffering from salivary gland hypofunction, as well as 58.2 % considered dryness of the mouth the most debilitating complication.
conclusionsConsidering the late effects assessed, the salivary gland hypofunction was the most significant and received the highest morbidity graduation (grade 2/grade 3); xerostomia was also considered the most debilitating complication after treatment. Data show the role of salivary gland hypofunction in the severity of late mucous membrane complication.
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Registered trials
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