ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Inhibitory morphogens and monopodial branching of the embryonic chicken lung.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.Cell reports · 2026Article
- Patterns of mitochondrial ATP predict tissue folding.Science advances · 2026Article
- TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.bioRxiv : the preprint server for biology · 2026Article
- Fluid secretion and luminal pressure control lateral branching morphogenesis in the embryonic avian lung.Developmental biology · 2025Article
- Zonal patterning of extracellular matrix and stromal cell populations along a perfusable cellular microchannel.Lab on a chip · 2024Article
- Zonal Patterning of Extracellular Matrix and Stromal Cell Populations Along a Perfusable Cellular Microchannel.bioRxiv : the preprint server for biology · 2024Article
- Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development.Advances in experimental medicine and biology · 2023Article
- Focal sources of FGF-10 promote the buckling morphogenesis of the embryonic airway epithelium.Biology open · 2022Article
- Negative Transpulmonary Pressure Disrupts Airway Morphogenesis by Suppressing Fgf10.Frontiers in cell and developmental biology · 2021Article
- Overactivity or blockade of transforming growth factor-β each generate a specific ureter malformation.The Journal of pathology · 2019Article
- Mesenchymal proteases and tissue fluidity remodel the extracellular matrix during airway epithelial branching in the embryonic avian lung.Development (Cambridge, England) · 2019Article
- Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback.Nature communications · 2019Article
- Mathematical Approaches of Branching Morphogenesis.Frontiers in genetics · 2018Review
- Retinoic acid regulates avian lung branching through a molecular network.Cellular and molecular life sciences : CMLS · 2017Article
- Morphogenesis and morphometric scaling of lung airway development follows phylogeny in chicken, quail, and duck embryos.EvoDevo · 2016Article
- Quantitative approaches to uncover physical mechanisms of tissue morphogenesis.Current opinion in biotechnology · 2013Review
- The control of branching morphogenesis.Open biology · 2013Review
- Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung.Development (Cambridge, England) · 2013Article
- Loss of cilia causes embryonic lung hypoplasia, liver fibrosis, and cholestasis in the talpid3 ciliopathy mutant.OrganogenesisArticle
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4 authors.
Funding
Abstract
backgroundBranching morphogenesis generates a diverse array of epithelial patterns, including dichotomous and monopodial geometries. Dichotomous branching can be instructed by concentration gradients of epithelial-derived inhibitory morphogens, including transforming growth factor-β (TGFβ), which is responsible for ramification of the pubertal mammary gland. Here, we investigated the role of autocrine inhibitory morphogens in monopodial branching morphogenesis of the embryonic chicken lung.
resultsComputational modeling and experiments using cultured organ explants each separately revealed that monopodial branching patterns cannot be specified by a single epithelial-derived autocrine morphogen gradient. Instead, signaling by means of TGFβ1 and bone morphogenetic protein-4 (BMP4) differentially affect the rates of branching and growth of the airways. Allometric analysis revealed that development of the epithelial tree obeys power-law dynamics; TGFβ1 and BMP4 have distinct but reversible effects on the scaling coefficient of the power law.
conclusionsThese data suggest that although autocrine inhibition cannot specify monopodial branching, inhibitory morphogens define the dynamics of lung morphogenesis.
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