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ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2012

Meningioma as second malignant neoplasm after oncological treatment during childhood.

H L Müller, U Gebhardt, M Warmuth-Metz, T Pietsch, N Sörensen, R-D Kortmann, study committee of HIT Endo

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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. What's in a name? Intracranial peripheral primitive neuroectodermal tumors and CNS primitive neuroectodermal tumors are not the same.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2013
    Pooled it
  2. Trial
  3. Article
  4. [Meningioma risk following treatment for childhood cancer. A pooled analysis].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Article
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  7. Review
  8. [Shoulder girdle, AC and SC joints].Operative Orthopadie und Traumatologie · 2014
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  9. Long-term results of total body irradiation in adults with acute lymphoblastic leukemia.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014
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  10. Secondary radiation dose during high-energy total body irradiation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014
    Article
  11. [Acute obstructive crisis ? Non-invasive ventilation ? Weaning long-term ventilation ].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014
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  12. Article
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  14. Can treatment of pediatric Hodgkin's lymphoma be improved by PET imaging and proton therapy?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2013
    Article
  15. Cephalometric assessment of the axial inclination of upper and lower incisors in relation to the third-order angle.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

H L MüllerDepartment of Pediatric Hematology and Oncology, Zentrum für Kinder- und Jugendmedizin, Klinikum Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Germany. mueller.hermann@klinikum-oldenburg.de
U Gebhardt
M Warmuth-Metz
T Pietsch
N Sörensen
R-D Kortmann
study committee of HIT Endo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A total of 38 patients (18 female/20 male) with childhood meningioma were recruited from the German registry HIT-Endo (1989-2009). In 5 cases meningioma occurred as second malignant neoplasm (SMN). Histologies were confirmed by reference assessment in all cases (SMN: 2 WHO I, 1 WHO II, 2 WHO III). The SMNs were diagnosed at a median age of 12.4 years with a median latency of 10.2 years after primary malignancy (PMN; 4 brain tumors, 1 lymphoblastic leukemia; median age at diagnosis 2.7 years). Meningioma occurred as SMN in the irradiated field of PMN (range 12-54 Gy). The outcome after treatment of SMN meningioma (surgery/irradiation) was favorable in terms of psychosocial status and functional capacity in 4 of 5 patients (1 death). We conclude that survivors of childhood cancer who were exposed to radiation therapy at young age harbor the risk of developing meningioma as a SMN at a particularly short latency period in case of high dose exposure.

Indexed as

AdolescentAntineoplastic AgentsBrain NeoplasmsChildChild, PreschoolHumansInfantMagnetic Resonance ImagingMaleMeningeal NeoplasmsMeningiomaPrecursor Cell Lymphoblastic Leukemia-LymphomaTreatment OutcomeAntineoplastic Agents

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.