Trial reportPediatric nephrology (Berlin, Germany)2012
Elevated urine levels of heparin-binding protein in children with urinary tract infection.
Trial report in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02533011 (Heparin Binding Protein), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Heparin Binding Protein (HBP) in Sepsis for the Prediction of Disease Progression
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Diagnostic accuracy of urine heparin binding protein for pediatric acute pyelonephritis.European journal of pediatrics · 2015Trial
- Diagnostic utility of the urine neutrophil CD64 ratio for patients with urinary tract infections.Frontiers in medicine · 2026Article
- Urinary Tract Infections Detection with Molecular Biomarkers.Biomolecules · 2024Review
- Comprehensive insights into UTIs: from pathophysiology to precision diagnosis and management.Frontiers in cellular and infection microbiology · 2024Review
- Reference Interval for the Axis-Shield Clinical Chemistry Heparin-Binding Protein Assay.Diagnostics (Basel, Switzerland) · 2022Article
- Application Value of Blood Heparin-Binding Protein in the Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.Contrast media & molecular imaging · 2021Article
- Heparin-binding protein measurement improves the prediction of myocardial injury-related cardiogenic shock.BMC cardiovascular disorders · 2020Observational
- Biomarkers in urinary tract infections - which ones are suitable for diagnostics and follow-up?GMS infectious diseases · 2020Review
- Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection in the Pediatric Neurogenic Bladder Population: NGAL As a Promising Biomarker.Topics in spinal cord injury rehabilitation · 2019Article
- Insight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Phenol-soluble modulin α4 mediates Staphylococcus aureus-associated vascular leakage by stimulating heparin-binding protein release from neutrophils.Scientific reports · 2016Article
- Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.Critical care medicine · 2015Observational
- The diagnosis of febrile urinary tract infection in children may be facilitated by urinary biomarkers.Pediatric nephrology (Berlin, Germany) · 2015Article
- Heparin-binding protein: a diagnostic biomarker of urinary tract infection in adults.Open forum infectious diseases · 2014Article
- Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care.Critical care (London, England) · 2013Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing.
methodsSeventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured.
resultsFifteen patients were classified as having UTI, 30 patients had fever but were diagnosed with a non-urinary tract infection, and 33 patients had neither UTI nor fever. Using a urine HBP (U-HBP) cut-off level of 32 ng/mL, the sensitivity and specificity for detecting UTI were 93.3 and 90.3 %, respectively. Receiver operating characteristic curves demonstrated that U-HBP levels were a higher specificity indicator of UTI than urine white blood cell counts or urine IL-6 levels; they also showed a higher sensitivity than the results of the urine nitrite test. All patients with significant growth of clinically relevant bacteria had elevated U-HBP levels.
conclusionThe results indicate that rapid analysis of U-HBP can provide helpful guidance in the management of children with suspected UTI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.