ArticleCritical care (London, England)2012
Serial soluble neurofilament heavy chain in plasma as a marker of brain injury after cardiac arrest.
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest.Critical care (London, England) · 2014Trial
- Multi-Modal Assessment of Cerebral Hemodynamics in Resuscitated Out-of-Hospital Cardiac Arrest Patients: A Case-Series.Life (Basel, Switzerland) · 2024Article
- Could MicroRNA be Neurological Prognosis Biomarkers after Cardiac Arrest?Turkish journal of anaesthesiology and reanimation · 2024Article
- Neurofilaments as biomarkers in neurological disorders - towards clinical application.Nature reviews. Neurology · 2024Review
- Article
- The 2022 Lady Estelle Wolfson lectureship on neurofilaments.Journal of neurochemistry · 2022Review
- Brain Injury Biomarkers for Predicting Outcome After Cardiac Arrest.Critical care (London, England) · 2022Review
- Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study.Critical care (London, England) · 2021Observational
- Neurologic prognostication after resuscitation from cardiac arrest.Journal of the American College of Emergency Physicians open · 2020Review
- Circulating Neurofilament Light Chain Is Associated With Survival After Pediatric Cardiac Arrest.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Article
- Risk Factors for Delayed Neurocognitive Recovery According to Brain Biomarkers and Cerebral Blood Flow Velocity.Medicina (Kaunas, Lithuania) · 2020Observational
- Neurofilaments in disease: what do we know?Current opinion in neurobiology · 2020Review
- Neurofilaments: The C-Reactive Protein of Neurology.Brain sciences · 2020Review
- Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest.JAMA neurology · 2019Article
- Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study.Critical care (London, England) · 2017Article
- Identification of novel biomarkers for prediction of neurological prognosis following cardiac arrest.Oncotarget · 2017Article
- Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study.Critical care (London, England) · 2014Observational
- How to assess prognosis after cardiac arrest and therapeutic hypothermia.Critical care (London, England) · 2014Review
- Increased neurofilament light chain blood levels in neurodegenerative neurological diseases.PloS one · 2013Article
- The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies.Multiple sclerosis international · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInduced hypothermia has been shown to improve outcome after cardiac arrest, but early prognostication is hampered by the need for sedation. Here we tested whether a biomarker for neurodegeneration, the neurofilament heavy chain (NfH), may improve diagnostic accuracy in the first days after cardiac arrest.
methodsThis prospective study included 90 consecutive patients treated with hypothermia after cardiac arrest. Plasma levels of phosphorylated NfH (SMI35) were quantified using standard ELISA over a period of 72 h after cardiac arrest. The primary outcome was the dichotomized Cerebral Performance Categories scale (CPC). A best CPC 1-2 during 6 months follow-up was considered a good outcome, a best CPC of 3-4 a poor outcome. Receiver operator characteristics and area under the curve were calculated.
resultsThe median age of the patients was 65 years, and 63 (70%) were male. A cardiac aetiology was identified in 62 cases (69%). 77 patients (86%) had out-of-hospital cardiac arrest. The outcome was good in 48 and poor in 42 patients. Plasma NfH levels were significantly higher 2 and 36 hours after cardiac arrest in patients with poor outcome (median 0.28 ng/mL and 0.5 ng/mL, respectively) compared to those with good outcome (0 ng/mL, p = 0.016, p < 0.005, respectively). The respective AUC were 0.72 and 0.71.
conclusionsPlasma NfH levels correlate to neurological prognosis following cardiac arrest. In this study, 15 patients had neurological co-morbidities and there was a considerable overlap of data. As such, neurofilament should not be used for routine neuroprognostication until more data are available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.