ArticleBrain research2012
Ethanol reduces the phase locking of neural activity in human and rodent brain.
Article in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Potentiation of the depressant effect of alcohol by flunitrazepam in rats: an electrocorticographic, respiratory and electrocardiographic study.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk.Behavioral sciences (Basel, Switzerland) · 2020Article
- PSPH-D-18-00526: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence.Psychopharmacology · 2020Article
- Effects of an Orexin-2 Receptor Antagonist on Sleep and Event-Related Oscillations in Female Rats Exposed to Chronic Intermittent Ethanol During Adolescence.Alcoholism, clinical and experimental research · 2020Article
- Phase locking of event-related oscillations is decreased in both young adult humans and rats with a history of adolescent alcohol exposure.Addiction biology · 2020Article
- Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits.Neuron · 2019Article
- Article
- Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach.Journal of psychopharmacology (Oxford, England) · 2019Article
- Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication.Journal of visualized experiments : JoVE · 2019Article
- Clarifying the neurobehavioral sequelae of moderate drinking lifestyles and acute alcohol effects with aging.International review of neurobiology · 2019Review
- Article
- Effect of Gabapentin on Sleep and Event-Related Oscillations (EROs) in Rats Exposed to Chronic Intermittent Ethanol Vapor and Protracted Withdrawal.Alcoholism, clinical and experimental research · 2018Article
- Article
- Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents.Behavioural brain research · 2017Article
- Effects of Age and Acute Moderate Alcohol Administration on Electrophysiological Correlates of Working Memory Maintenance.Alcoholism, clinical and experimental research · 2016Article
- Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Article
- Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2015Article
- Ontogeny and adolescent alcohol exposure in Wistar rats: open field conflict, light/dark box and forced swim test.Pharmacology, biochemistry, and behavior · 2014Article
- Cholinergic modulation of event-related oscillations (ERO).Brain research · 2014Article
- Event-related potential responses to the acute and chronic effects of alcohol in adolescent and adult Wistar rats.Alcoholism, clinical and experimental research · 2014Article
Corrections and comments
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3 authors.
Funding
Abstract
How the neuromolecular actions of ethanol translate to its observed intoxicating effects remains poorly understood. Synchrony of phase (phase locking) of event-related oscillations (EROs) within and between different brain areas has been suggested to reflect communication exchange between neural networks and as such may be a sensitive and translational measure of ethanol's effects. Using a similar auditory event-related potential paradigm in both rats and humans we investigated the phase variability of EROs collected from 38 young men who had participated in an ethanol/placebo challenge protocol, and 46 adult male rats given intraperitoneal injections of ethanol/saline. Phase locking was significantly higher in the delta frequencies in humans than in rats. Phase locking was also higher for the rare (target) tone than the frequent (non-target) tone in both species. Significant reductions in phase locking to the rare (target) tone in the delta, theta, alpha, beta and gamma frequencies, within and between brain sites, was found at 1h following ethanol as compared to placebo/saline administration in both rats and humans. Reductions in phase locking in the alpha frequencies in the parietal cortex were found to be correlated with blood ethanol concentrations. These findings are consistent with the hypothesis that ethanol's intoxicating actions in the brain include reducing synchrony within and between neuronal networks, perhaps by increasing the level of noise in key neuromolecular interactions.
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