ArticleCurrent opinion in neurobiology2012
Pain processing by spinal microcircuits: afferent combinatorics.
Article in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation.PloS one · 2014Trial
- Dual-frequency spinal cord stimulation increases responder rates for treatment of neuropathic pain.Pain · 2026Article
- The neuronal circuits and cellular encoding of thermosensation.Nature reviews. Neuroscience · 2026Review
- Synaptic-immune interactions in neuropathic pain: complement-mediated remodeling of spinal dorsal horn microcircuits.Frontiers in cell and developmental biology · 2026Review
- Mrgprb4-lineage neurons indispensable in pressure induced pleasant sensation are polymodal.iScience · 2025Article
- Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reproducible and fully automated testing of nocifensive behavior in mice.Cell reports methods · 2023Article
- Revisiting a classical theory of sensory specificity: assessing consistency and stability of thermosensitive spots.Journal of neurophysiology · 2023Article
- Article
- Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain.Neuron · 2022Article
- Transient and Steady-State Properties ofFrontiers in cellular neuroscience · 2022Article
- Modality-Specific Modulation of Temperature Representations in the Spinal Cord after Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.International journal of molecular sciences · 2021Review
- Article
- Organization of the Thermal Grill Illusion by Spinal Segments.Annals of neurology · 2018Article
- Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons.The Journal of physiology · 2018Article
- Identifying local and descending inputs for primary sensory neurons.The Journal of clinical investigation · 2015Article
- Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control.Journal of neurophysiology · 2015Article
- Sensory-evoked perturbations of locomotor activity by sparse sensory input: a computational study.Journal of neurophysiology · 2015Article
- Thermosensory processing in the Drosophila brain.Nature · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
Pain, itch, heat, cold, and touch represent different percepts arising from somatosensory input. How stimuli give rise to these percepts has been debated for over a century. Recent work supports the view that primary afferents are highly specialized to transduce and encode specific stimulus modalities. However, cross-modal interactions (e.g. inhibition or exacerbation of pain by touch) support convergence rather than specificity in central circuits. We outline how peripheral specialization together with central convergence could enable spinal microcircuits to combine inputs from distinctly specialized, co-activated afferents and to modulate the output signals thus formed through computations like normalization. These issues will be discussed alongside recent advances in our understanding of microcircuitry in the superficial dorsal horn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.