ArticleHead & neck oncology2012
The effect of tobacco and alcohol and their reduction/cessation on mortality in oral cancer patients: short communication.
Article in Head & neck oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 37 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Quality of smoking cessation advice in guidelines of tobacco-related diseases: An updated systematic review.Clinical medicine (London, England) · 2020Pooled it
- Systematic Review of Tobacco Use after Lung or Head/Neck Cancer Diagnosis: Results and Recommendations for Future Research.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Pooled it
- Trial
- Identification of high-risk patients and metastatic progression in primary c/pN0 oral squamous cell carcinoma.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Ethanol exposure promotes tumor cell migration and angiogenesis in a mouse model of glioblastoma.Alcohol (Fayetteville, N.Y.) · 2025Article
- Motivation for Smoking Cessation in Patients With Oral Squamous Cell Carcinoma-A One-Time Survey.Clinical and experimental dental research · 2025Article
- History of Oral Mucosal Lesions in Oral Squamous Cell Carcinoma Patients.Oral health & preventive dentistry · 2025Article
- Study on the disease burden of lip and oral cancer attributable to tobacco use: based on the 2021 Global Burden of Disease study.Frontiers in oncology · 2025Article
- Oral squamous cell carcinoma: Effect of tobacco and alcohol on cancer location.Tobacco induced diseases · 2024Article
- The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair.Frontiers in pharmacology · 2024Article
- The mortality of oral cancer attributable to tobacco in China, the US, and India.Journal of cancer research and clinical oncology · 2023Article
- Serum autoantibody profiling of oral squamous cell carcinoma patients reveals NUBP2 as a potential diagnostic marker.Frontiers in oncology · 2023Article
- Circulating Vimentin Over-Expression in Patients with Oral Sub Mucosal Fibrosis and Oral Squamous Cell Carcinoma.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- A national study of alcohol consumption patterns among population-based U.S. cancer survivors compared with cancer-free individuals.Cancer epidemiology · 2022Article
- Smoking trajectory and cancer risk: A population-based cohort study.Tobacco induced diseases · 2022Article
- Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies.Cancers · 2021Review
- Preoperative C-reactive protein to albumin ratio and oral health in oral squamous cell carcinoma patients.BMC oral health · 2021Article
- Cigarette-smoking characteristics and interest in cessation in patients with head-and-neck cancer.Current oncology (Toronto, Ont.) · 2020Article
- The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.Expert reviews in molecular medicine · 2020Review
- Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma.PLoS genetics · 2019Article
Corrections and comments
- Expression of concern
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of tobacco is known to increase the incidence of developing oral cancer by 6 times, while the additive effect of drinking alcohol further increases the risk leading to higher rate of morbidity and mortality. In this short communication, we prospectively assessed the effect of tobacco smoking and alcohol drinking in oral cancer patients on the overall mortality from the disease, as well as the effect of smoking and drinking reduction/cessation at time of diagnosis on mortality in the same group. MATERIALS AND
methodsA cohort, involved 67 male patients who were diagnosed with oral squamous cell carcinoma, was included in this study. The smoking and drinking habits of this group were recorded, in addition to reduction/cessation after diagnosis with the disease. Comparisons were made to disease mortality at 3 and 5 years.
resultsFollow-up resulted in a 3-year survival of 46.8% and a 5-year survival of 40.4%. Reduction of tobacco smoking and smoking cessation led to a significant reduction in mortality at 3 (P < 0.001) and 5 (P < 0.001) years. Reduction in drinking alcohol and drinking cessation led to a significant reduction in mortality at 3 (P < 0.001) and 5 (P < 0.001) years.
conclusionChronic smoking and drinking does have an adverse effect on patients with oral cancer leading to increased mortality from cancer-related causes. Reduction/cessation of these habits tends to significantly reduce mortality in this group of patients. Smoking and drinking cessation counseling should be provided to all newly diagnosed oral cancer patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.