ArticleBMC microbiology2012
Alternative sigma factor σH activates competence gene expression in Lactobacillus sakei.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Multi-omics analysis reveals the genetic basis for rapid COmSystems · 2025Article
- Expanding natural transformation to improve beneficial lactic acid bacteria.FEMS microbiology reviews · 2022Article
- Environmental Impact on Differential Composition of Gut Microbiota in Indoor Chickens in Commercial Production and Outdoor, Backyard Chickens.Microorganisms · 2020Article
- Unleashing Natural Competence in Lactococcus lactis by Induction of the Competence Regulator ComX.Applied and environmental microbiology · 2017Article
- Natural DNA Transformation Is Functional in Lactococcus lactis subsp. cremoris KW2.Applied and environmental microbiology · 2017Article
- Silently transformable: the many ways bacteria conceal their built-in capacity of genetic exchange.Current genetics · 2017Review
- Listeria monocytogenes σH Contributes to Expression of Competence Genes and Intracellular Growth.Journal of bacteriology · 2016Article
- Bacterial transformation: distribution, shared mechanisms and divergent control.Nature reviews. Microbiology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlternative sigma factors trigger various adaptive responses. Lactobacillus sakei, a non-sporulating meat-borne bacterium, carries an alternative sigma factor seemingly orthologous to σ(H) of Bacillus subtilis, best known for its contribution to the initiation of a large starvation response ultimately leading to sporulation. As the role of σ(H)-like factors has been little studied in non-sporulating bacteria, we investigated the function of σ(H) in L. sakei.
resultsTranscription of sigH coding for σ(H) was hardly affected by entry into stationary phase in our laboratory conditions. Twenty-five genes potentially regulated by σ(H) in L. sakei 23 K were revealed by genome-wide transcriptomic profiling of sigH overexpression and/or quantitative PCR analysis. More than half of them are involved in the synthesis of a DNA uptake machinery linked to genetic competence, and in DNA metabolism; however, σ(H) overproduction did not allow detectable genetic transformation. σ(H) was found to be conserved in the L. sakei species.
conclusionOur results are indicative of the existence of a genetic competence state activated by σ(H) in L. sakei, and sustain the hypothesis that σ(H)-like factors in non sporulating Firmicutes share this common function with the well-known ComX of naturally transformable streptococci.
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