ArticleBMC genomics2012
Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
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- The pan-genome of Mycobacterium avium subsp. paratuberculosis (Map) confirms ancestral lineage and reveals gene rearrangements within Map Type S.BMC genomics · 2023Article
- Cold Cas: reevaluating the occurrence of CRISPR/Cas systems inFrontiers in microbiology · 2023Article
- Global Phylogeny ofFrontiers in microbiology · 2022Article
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- Evolutionary genomic and bacteria GWAS analysis ofApplied and environmental microbiology · 2021Article
- Comparative genomic analysis of Mycobacterium intracellulare: implications for clinical taxonomic classification in pulmonary Mycobacterium avium-intracellulare complex disease.BMC microbiology · 2021Article
- Molecular characterisation of Mycobacterium avium subsp. paratuberculosis in Australia.BMC microbiology · 2021Article
- Complete Genome Sequence of a Type III Ovine Strain of Mycobacterium avium subsp.Microbiology resource announcements · 2021Article
- Whole-Genome Analysis ofFrontiers in microbiology · 2021Article
- Comparative Genomics ofFrontiers in veterinary science · 2021Article
- Complete Genome Sequence of OvineMicroorganisms · 2020Article
- Genetic Diversity AmongFrontiers in microbiology · 2020Article
- Complete Genome Sequence of the Telford Type S Strain of Mycobacterium avium subsp. paratuberculosis.Microbiology resource announcements · 2019Article
- Membrane and Cytoplasmic Proteins ofMicroorganisms · 2018Article
- Genotyping methods and molecular epidemiology ofInternational journal of veterinary science and medicine · 2018Review
- EnvironmentalFrontiers in cellular and infection microbiology · 2018Article
- Identification ofCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2017Article
- Pathogenesis, Molecular Genetics, and Genomics ofFrontiers in veterinary science · 2017Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genome of Mycobacterium avium subspecies paratuberculosis (MAP) is remarkably homogeneous among the genomes of bovine, human and wildlife isolates. However, previous work in our laboratories with the bovine K-10 strain has revealed substantial differences compared to sheep isolates. To systematically characterize all genomic differences that may be associated with the specific hosts, we sequenced the genomes of three U.S. sheep isolates and also obtained an optical map.
resultsOur analysis of one of the isolates, MAP S397, revealed a genome 4.8 Mb in size with 4,700 open reading frames (ORFs). Comparative analysis of the MAP S397 isolate showed it acquired approximately 10 large sequence regions that are shared with the human M. avium subsp. hominissuis strain 104 and lost 2 large regions that are present in the bovine strain. In addition, optical mapping defined the presence of 7 large inversions between the bovine and ovine genomes (~ 2.36 Mb). Whole-genome sequencing of 2 additional sheep strains of MAP (JTC1074 and JTC7565) further confirmed genomic homogeneity of the sheep isolates despite the presence of polymorphisms on the nucleotide level.
conclusionsComparative sequence analysis employed here provided a better understanding of the host association, evolution of members of the M. avium complex and could help in deciphering the phenotypic differences observed among sheep and cattle strains of MAP. A similar approach based on whole-genome sequencing combined with optical mapping could be employed to examine closely related pathogens. We propose an evolutionary scenario for M. avium complex strains based on these genome sequences.
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