Evidence map›Paper›PMID 22409270›Full record

ReviewVeterinary dermatology2012

Antimicrobial peptides: agents of border protection for companion animals.

Brian C Leonard, Verena K Affolter, Charles L Bevins

Abstract readReview
In one paragraph

Review in Veterinary dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?International journal of molecular sciences · 2020
    Review
  8. Highly synergistic activity of melittin with imipenem and colistin in biofilm inhibition against multidrug-resistant strong biofilm producer strains of Acinetobacter baumannii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brian C LeonardDepartment of Microbiology and Immunology, UC Davis School of Medicine, Davis, CA 95616, USA.
Verena K Affolter
Charles L Bevins
University of California, Davis · US

Funding

Novel Defensins in Human Epithelial TissuesR37AI032738 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEVINS, CHARLES L · 2015 to 2022
$3.1M
Host Interactions of Salmonella typhimuriumR01AI076246 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ADAMS, LESLIE GARRY, BAUMLER, ANDREAS J · 2009 to 2013
$2.7M
Novel Defensins of Human EpitheliaR01AI032738 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BEVINS, CHARLES L · 1993 to 2009
$2.3M
In vivo Models of Defensin ActivityR01AI050843 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BEVINS, CHARLES L · 2002 to 2006
$1.6M
Year-Long Exposure to Advanced Research (YEAR) Program for Vet StudentsT32RR021312 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LLOYD, KC KENT · 2005 to 2011
$665k
NCRR NIH HHS T32RR021312,NIAID NIH HHS AI032738NIAID NIH HHS AI076246NIAID NIH HHS AI50843NIAID NIH HHS R01 AI032738NIAID NIH HHS R01 AI050843NIAID NIH HHS R01 AI076246NIAID NIH HHS R37 AI032738PHS HHS T32A160555
6 · The paper itself

Abstract

Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis. In addition to direct antimicrobial activity, these peptides participate in many cellular functions, including chemotaxis, wound healing and even determination of canine coat colour. Various biological and genetic approaches have helped to elucidate the role of antimicrobial peptides with respect to innate immunity and host defense. Associations of antimicrobial peptides with various skin diseases, including psoriasis, rosacea and atopic dermatitis, have been documented in humans. In the longer term, therapeutic modulation of antimicrobial peptide expression may provide effective new treatments for disease. This review highlights current knowledge about antimicrobial peptides of the skin and circulating leukocytes, with particular focus on relevance to physiology and disease in companion animals.

Indexed as

AnimalsAntimicrobial Cationic PeptidesBacterial InfectionsCathelicidinsChemotaxisDefensinsDermatitis, AtopicDogsHair ColorHumansPsoriasisAntimicrobial Cationic PeptidesCathelicidinsDefensins

Identifiers

PMID22409270
PMCPMC3467306
OpenAlexW1493735200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.