ArticleThe journal of physical chemistry. B2012
On the morphology of viral capsids: elastic properties and buckling transitions.
Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail.Science advances · 2025Article
- Elasticity of the HIV-1 core facilitates nuclear entry and infection.PLoS pathogens · 2024Article
- Embracing nanomaterials' interactions with the innate immune system.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Single-particle virology.Biophysical reviews · 2020Review
- Surface stresses in complex viral capsids and non-quasi-equivalent viral architectures.Journal of the Royal Society, Interface · 2020Article
- Electrostatics-Driven Inflation of Elastic Icosahedral Shells as a Model for Swelling of Viruses.Biophysical journal · 2018Article
- Viral nanomechanics with a virtual atomic force microscope.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Post-buckling of a pressured biopolymer spherical shell with the mode interaction.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- Article
- A Non-Symmetric Reconstruction Technique for Transcriptionally-Active Viral Assemblies.Journal of analytical & molecular techniques · 2015Article
- Stability of Norwalk Virus Capsid Protein Interfaces Evaluated by in Silico Nanoindentation.Frontiers in bioengineering and biotechnology · 2015Article
- Recent Developments in Molecular Simulation Approaches to Study Spherical Virus Capsids.Molecular simulation · 2014Article
- Theoretical frameworks for multiscale modeling and simulation.Current opinion in structural biology · 2014Review
- Collective variable approaches for single molecule flexible fitting and enhanced sampling.Chemical reviews · 2014Review
- pH-induced stability switching of the bacteriophage HK97 maturation pathway.Journal of the American Chemical Society · 2014Article
- Statistical analysis of sizes and shapes of virus capsids and their resulting elastic properties.Journal of biological physics · 2013Article
- Modeling Viral Capsid Assembly.Advances in chemical physicsArticle
- Highly Symmetric and Congruently Tiled Meshes for Shells and Domes.Procedia engineeringArticle
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Authors and funding
2 authors.
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Abstract
The morphology of icosahedral viruses ranges from highly spherical to highly faceted, and for some viruses a shape transition occurs during the viral life cycle. This phenomena is predicted from continuum elasticity, via the buckling transition theory by Nelson (Phys. Rev. E 2003, 68, 051910), in which the shape is dependent on the Foppl-von Kármán number (γ), which is a ratio of the two-dimensional Young's modulus (Y) and the bending modulus (κ). However, until now, no direct calculations have been performed on atomic-level capsid structures to test the predictions of the theory. In this study, we employ a previously described multiscale method by May and Brooks (Phys. Rev. Lett. 2011, 106, 188101) to calculate Y and κ for the bacteriophage HK97, which undergoes a spherical to faceted transition during its viral life cycle. We observe a change in γ consistent with the buckling transition theory and also a significant reduction in κ, which facilitates formation of the faceted state. We go on to examine many capsids from the T = 3 and 7 classes using only elastic network models, which allows us to calculate the ratio Y/κ, without the expense of all-atom molecular dynamics. We observe for the T = 7 capsids, there is strong correlation between the shape of the capsid and γ; however, there is no such correlation for the smaller T = 3 viruses.
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