ArticleNorth American journal of medical sciences2012
Drug-induced hepatotoxicity in a tertiary care hospital in rural South India.
Article in North American journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Drug induced liver injury: East versus West - a systematic review and meta-analysis.Clinical and molecular hepatology · 2020Pooled it
- Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission.PLoS neglected tropical diseases · 2016Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundLiver is the main organ for metabolism of drugs and hepatotoxicity is a potential adverse effect for most drugs.
aimsThis study was to study the frequency of drug-induced hepatotoxicity and to find the common drugs causing hepatotoxicity. MATERIALS AND
methodsThe study was conducted at a tertiary care hospital in rural India. It is a study based on case series analysis. All patients with an abnormal liver function report, between July 2006 and July 2007, were included in the study
resultsThe study included 411 patients. Among them 141 patients were females and 270 males. The common cause for abnormal liver function was alcoholic liver disease (30.4%) followed by drug-induced hepatotoxicity (15.8%) and malaria (15.3%). Drug-induced hepatotoxicity was seen in 65 patients. It was common in males (55%) compared to females (44%). The mean age of the patients with drug-induced hepatotoxicity was 43±15.9. Antitubercular drugs were the commonly encountered drugs (44%) causing hepatotoxicity followed by lipid lowering agents (41%). The others drugs included antiretroviral drugs (6%),steroids (5%) and chlorpromazine (2%).
conclusionA thorough history of drug intake must be taken in all patients presenting with abnormal hepatic function.
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