ArticleFrontiers in systems neuroscience2012
Tinnitus: pathology of synaptic plasticity at the cellular and system levels.
Article in Frontiers in systems neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03365011 (Nitrous Oxide as Treatment for Tinnitus), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial
Who cites it
24 citing papers in PubMed.
- Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2018Trial
- Efficacy and safety of AM-101 in the treatment of acute inner ear tinnitus--a double-blind, randomized, placebo-controlled phase II study.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2014Trial
- Disproportionality analysis of drug-associated tinnitus safety signals: a 43-year pharmacovigilance study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The association between stress, emotional states, and tinnitus: a mini-review.Frontiers in aging neuroscience · 2023Review
- Tinnitus: at a crossroad between phantom perception and sleep.Brain communications · 2022Review
- Global research hot spot and trends in tinnitus treatment between 2000 and 2021: A bibliometric and visualized study.Frontiers in neurology · 2022Article
- Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study.EBioMedicine · 2021Article
- Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Tinnitus Is Associated With Improved Cognitive Performance in Non-hispanic Elderly With Hearing Loss.Frontiers in neuroscience · 2021Article
- Tinnitus Update.Journal of clinical neurology (Seoul, Korea) · 2021Review
- Article
- The Characteristic and Short-Term Prognosis of Tinnitus Associated with Sudden Sensorineural Hearing Loss.Neural plasticity · 2018Article
- Pathophysiology of Subjective Tinnitus: Triggers and Maintenance.Frontiers in neuroscience · 2018Review
- Saturation of long-term potentiation in the dorsal cochlear nucleus and its pharmacological reversal in an experimental model of tinnitus.Experimental neurology · 2017Article
- Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in Chronic Tinnitus.Frontiers in neuroscience · 2017Article
- Characteristics and Spontaneous Recovery of Tinnitus Related to Idiopathic Sudden Sensorineural Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2016Article
- Noise Trauma Induced Neural Plasticity Throughout the Auditory System of Mongolian Gerbils: Differences between Tinnitus Developing and Non-Developing Animals.Frontiers in neurology · 2015Article
- Underlying mechanisms of tinnitus: review and clinical implications.Journal of the American Academy of Audiology · 2014Review
- Telemedicine in tinnitus: feasibility, advantages, limitations, and perspectives.ISRN otolaryngology · 2013Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite being more and more common, and having a high impact on the quality of life of sufferers, tinnitus does not yet have a cure. This has been mostly the result of limited knowledge of the biological mechanisms underlying this adverse pathology. However, the last decade has witnessed tremendous progress in our understanding on the pathophysiology of tinnitus. Animal models have demonstrated that tinnitus is a pathology of neural plasticity, and has two main components: a molecular, peripheral component related to the initiation phase of tinnitus; and a system-level, central component-related to the long-term maintenance of tinnitus. Using the most recent experimental data and the molecular/system dichotomy as a framework, we describe here the biological basis of tinnitus. We then discuss these mechanisms from an evolutionary perspective, highlighting similarities with memory. Finally, we consider how these discoveries can translate into therapies, and we suggest operative strategies to design new and effective combined therapeutic solutions using both pharmacological (local and systemic) and behavioral tools (e.g., using tele-medicine and virtual reality settings).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.