Evidence map›Paper›PMID 22408441›Full record

ArticleInternational journal of molecular sciences2012

The effect of toll-like receptor 4 in the aqueous humor of endotoxin-induced uveitis.

Jing Wang, Hong Lu, Yingzhi Xu, Xiaofeng Hu, Wei Chen, Shang Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jing WangDepartment of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
Hong LuDepartment of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
Yingzhi XuDepartment of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
Xiaofeng HuDepartment of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
Wei ChenDepartment of Ophthalmology, Haidian Maternal and Child Health Hospital, Tongji Medical University, Beijing 100080, China.
Shang LiDepartment of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
Beijing Chaoyang Emergency Medical Center · CNCapital Medical University · CNHainan Maternal and Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.

Indexed as

AnimalsAqueous HumorEndotoxinsInterferon-gammaInterleukin-1Interleukin-10Interleukin-6LipopolysaccharidesMaleMiceMice, Inbred C3HSignal TransductionToll-Like Receptor 4Tumor Necrosis Factor-alphaUveitisEndotoxinsInterferon-gammaInterleukin-1Interleukin-10Interleukin-6LipopolysaccharidesToll-Like Receptor 4Tumor Necrosis Factor-alphaAnterior Uveitisaqueous humorCytokinecytometric bead array technologyToll-like receptor 4

Identifiers

PMID22408441
PMCPMC3292010
OpenAlexW1989601350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.