Evidence map›Paper›PMID 22408401›Full record

Trial reportInternational journal of molecular sciences2012

Elevated peripheral blood plasma concentrations of tie-2 and angiopoietin 2 in patients with neuroendocrine tumors.

Gabriela Melen-Mucha, Agata Niedziela, Slawomir Mucha, Ewelina Motylewska, Hanna Lawnicka, Jan Komorowski, Henryk Stepien

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Review
  12. Article
  13. Circulating serum levels of angiopoietin-1 and angiopoietin-2 in nasopharynx and larynx carcinoma patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gabriela Melen-MuchaDepartment of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr Sterling Str. No. 3, 91-425 Lodz, Poland.
Agata NiedzielaDepartment of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr Sterling Str. No. 3, 91-425 Lodz, Poland.
Slawomir MuchaDepartment of Clinical Endocrinology, Chair of Endocrinology, Medical University of Lodz, Dr Sterling Str. No. 3, 91-425 Lodz, Poland.
Ewelina MotylewskaDepartment of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr Sterling Str. No. 3, 91-425 Lodz, Poland.
Hanna LawnickaDepartment of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr Sterling Str. No. 3, 91-425 Lodz, Poland.
Jan KomorowskiDepartment of Clinical Endocrinology, Chair of Endocrinology, Medical University of Lodz, Dr Sterling Str. No. 3, 91-425 Lodz, Poland.
Henryk StepienDepartment of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr Sterling Str. No. 3, 91-425 Lodz, Poland.
Medical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastro-entero-pancreatic/neuroendocrine (NET) tumors are highly vascularized neoplasms. However, our knowledge concerning circulating levels of the angiogenic factors in NET patients still remains insufficient.

methodsThe aim of this study was to measure plasma concentrations of VEGF, angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2), soluble Tie-2, endostatin, osteopontin (OPN) and chromogranin A (CgA) in 36 NET patients and 16 controls.

resultsOnly the plasma concentrations of Tie-2 and CgA were higher in NET patients as compared to controls. These levels were within the reference range in controls; however one control demonstrated slightly elevated Tie-2 and 4 elevated CgA. Similarly, in the subgroup of patients with carcinoid syndrome, only Tie-2 and CgA concentrations were higher than those in patients with non-functioning NETs. In turn, in the subgroup of metastatic patients, only Ang-2 levels were higher than in those with localized disease. A positive correlation was found between Ang-2 and Tie-2 levels in metastatic patients and between Ang-1 and Tie-2 in localized NETs.

conclusionsThe plasma concentration of Tie-2 is proposed as an additional marker for NET patients and seems to be similarly effective as the currently used CgA level. Moreover, higher plasma levels of Ang-2 together with the positive correlation between Ang-2 and Tie-2 levels in metastatic subjects, implies that cases with a Tie-2 level above the upper limits, together with higher level of Ang-2 seem to be highly predictive of metastases.

Indexed as

Carcinoma, NeuroendocrineAdultAgedAged, 80 and overAngiopoietin-2Biomarkers, TumorChromogranin AEndostatinsFemaleHumansMaleMiddle AgedNeoplasm MetastasisNeoplasm ProteinsOsteopontinReceptor, TIE-2Angiopoietin-2ANGPT2 protein, humanBiomarkers, TumorCHGA protein, humanChromogranin AEndostatinsNeoplasm ProteinsOsteopontinReceptor, TIE-2Ang-1Ang-2angiogenic factorsNET patientsTie-2

Identifiers

PMID22408401
PMCPMC3291970
OpenAlexW2111127962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.