ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Theoretical comparison of wall-derived and erythrocyte-derived mechanisms for metabolic flow regulation in heterogeneous microvascular networks.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Metabolic blood flow regulation in a hybrid model of the human retinal microcirculation.Mathematical biosciences · 2023Article
- Application of machine learning in predicting blood flow and red cell distribution in capillary vessel networks.Journal of the Royal Society, Interface · 2022Article
- Functional implications of microvascular heterogeneity for oxygen uptake and utilization.Physiological reports · 2022Review
- A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks.Scientific reports · 2022Article
- Physical Properties of Blood and their Relationship to Clinical Conditions.Frontiers in physiology · 2022Review
- Modeling acute and chronic vascular responses to a major arterial occlusion.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Blood flow regulation and oxygen transport in a heterogeneous model of the mouse retina.Mathematical biosciences · 2020Article
- Influence of feeding hematocrit and perfusion pressure on hematocrit reduction (Fåhraeus effect) in an artificial microvascular network.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Structural Control of Microvessel Diameters: Origins of Metabolic Signals.Frontiers in physiology · 2017Article
- Open-loop (feed-forward) and feedback control of coronary blood flow during exercise, cardiac pacing, and pressure changes.American journal of physiology. Heart and circulatory physiology · 2016Article
- Structure-based algorithms for microvessel classification.Microcirculation (New York, N.Y. : 1994) · 2015Article
- Oxygen transport in a cross section of the rat inner medulla: impact of heterogeneous distribution of nephrons and vessels.Mathematical biosciences · 2014Article
- Commentaries on viewpoint: A paradigm shift for local blood flow regulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation.Frontiers in physiology · 2014Article
- Capillary recruitment in a theoretical model for blood flow regulation in heterogeneous microvessel networks.Physiological reports · 2013Article
- The vascular conducted response in cerebral blood flow regulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- Oxygen transport in the microcirculation and its regulation.Microcirculation (New York, N.Y. : 1994) · 2013Review
- What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?Microcirculation (New York, N.Y. : 1994) · 2012Review
- Toward a multiscale description of microvascular flow regulation: o(2)-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The objective of this study is to compare the effectiveness of metabolic signals derived from erythrocytes and derived from the vessel wall for regulating blood flow in heterogeneous microvascular networks. A theoretical model is used to simulate blood flow, mass transport, and vascular responses. The model accounts for myogenic, shear-dependent, and metabolic flow regulation. Metabolic signals are assumed to be propagated upstream along vessel walls via a conducted response. Arteriolar tone is assumed to depend on the conducted metabolic signal as well as local wall shear stress and wall tension, and arteriolar diameters are calculated based on vascular smooth muscle mechanics. The model shows that under certain conditions metabolic regulation based on wall-derived signals can be more effective in matching perfusion to local oxygen demand relative to regulation based on erythrocyte-derived signals, resulting in higher extraction and lower oxygen deficit. The lower effectiveness of the erythrocyte-derived signal is shown to result in part from the unequal partition of hematocrit at diverging bifurcations, such that low-flow vessels tend to receive a reduced hematocrit and thereby experience a reduced erythrocyte-derived metabolic signal. The model simulations predict that metabolic signals independent of erythrocytes may play an important role in local metabolic regulation of vascular tone and flow distribution in heterogeneous microvessel networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.