ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Use of endogenous NADH fluorescence for real-time in situ visualization of epicardial radiofrequency ablation lesions and gaps.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Stretchable large-area transparent nanowire composite arrays for label-free multimodal interrogation of cardiac physiology.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Understanding Lesion Creation Biophysics and Improved Lesion Assessment during Radiofrequency Catheter Ablation. The Perfect Combination to Achieve Durable Lesions in Atrial Fibrillation Ablation.Reviews in cardiovascular medicine · 2024Review
- Robust, high-density lesion mapping in the left atrium with near-infrared spectroscopy.Journal of biomedical optics · 2024Article
- Monitoring of irrigated lesion formation with single fiber based multispectral system using machine learning.Journal of biophotonics · 2022Article
- Cardiac endocardial left atrial substrate and lesion depth mapping using near-infrared spectroscopy.Biomedical optics express · 2022Article
- Open-source low-cost cardiac optical mapping system.PloS one · 2022Article
- Quantification of irrigated lesion morphology using near-infrared spectroscopy.Scientific reports · 2021Article
- Catheter ablation for atrial fibrillation: current indications and evolving technologies.Nature reviews. Cardiology · 2021Review
- KairoSight: Open-Source Software for the Analysis of Cardiac Optical Data Collected From Multiple Species.Frontiers in physiology · 2021Article
- Autofluorescence properties of balloon polymers used in medical applications.Journal of biomedical optics · 2020Article
- Towards real-time multispectral endoscopic imaging for cardiac lesion quality assessment.Biomedical optics express · 2019Article
- Optical coherence tomography imaging of cardiac substrates.Quantitative imaging in medicine and surgery · 2019Review
- Real-time optical spectroscopic monitoring of nonirrigated lesion progression within atrial and ventricular tissues.Journal of biophotonics · 2019Article
- Optimization of wavelength selection for multispectral image acquisition: a case study of atrial ablation lesions.Biomedical optics express · 2018Article
- Hyperspectral imaging for label-free in vivo identification of myocardial scars and sites of radiofrequency ablation lesions.Heart rhythm · 2018Article
- Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography.Biophysical journal · 2018Article
- Catheter Ablation of Atrial Fibrillation: A Review of the Current Status and Future Directions.The Journal of innovations in cardiac rhythm management · 2017Review
- Autofluorescence hyperspectral imaging of radiofrequency ablation lesions in porcine cardiac tissue.Journal of biophotonics · 2017Article
- Seeing the Invisible: Revealing Atrial Ablation Lesions Using Hyperspectral Imaging Approach.PloS one · 2016Article
- Physiological response of cardiac tissue to bisphenol A: alterations in ventricular pressure and contractility.American journal of physiology. Heart and circulatory physiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Radiofrequency ablation (RFA) aims to produce lesions that interrupt reentrant circuits or block the spread of electrical activation from sites of abnormal activity. Today, there are limited means for real-time visualization of cardiac muscle tissue injury during RFA procedures. We hypothesized that the fluorescence of endogenous NADH could be used as a marker of cardiac muscle injury during epicardial RFA procedures. Studies were conducted in blood-free and blood-perfused hearts from healthy adult Sprague-Dawley rats and New Zealand rabbits. Radiofrequency was applied to the epicardial surface of the heart using a 4-mm standard blazer ablation catheter. A dual camera optical mapping system was used to monitor NADH fluorescence upon ultraviolet illumination of the epicardial surface and to record optical action potentials using the voltage-sensitive probe RH237. Epicardial lesions were seen as areas of low NADH fluorescence. The lesions appeared immediately after ablation and remained stable for several hours. Real-time monitoring of NADH fluorescence allowed visualization of viable tissue between the RFA lesions. Dual recordings of NADH and epicardial electrical activity linked the gaps between lesions to postablation reentries. We found that the fluorescence of endogenous NADH aids the visualization of injured epicardial tissue caused by RFA. This was true for both blood-free and blood-perfused preparations. Gaps between NADH-negative regions revealed unablated tissue, which may promote postablation reentry or provide pathways for the conduction of abnormal electrical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.