ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2012
Temporal trends and determinants of longitudinal change in 25-hydroxyvitamin D and parathyroid hormone levels.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Vitamin D deficiency as a risk factor for dementia: a systematic review and meta-analysis.BMC geriatrics · 2017Pooled it
- Vitamin D and calcium status in HYDRIA, Greece: associations with dietary and supplemental sources.European journal of nutrition · 2026Article
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- Association between creatinine clearance and mortality in Chinese patients with osteoporotic fractures: a retrospective cohort study.Frontiers in medicine · 2025Article
- Prevalence of low vitamin D status in an urban district in Sri Lanka: a population-based study.BMC nutrition · 2024Article
- Vitamin D Status among 2-18-Year-Old Romanian Pediatric Patients: A Single-Center Study.Nutrients · 2024Article
- Geographic variation in bone mineral density and prevalent fractures in the Canadian longitudinal study on aging.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
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- Vitamin D status of the Russian adult population from 2013 to 2018.Scientific reports · 2022Article
- Trends in Vitamin D Status Around the World.JBMR plus · 2021Article
- Tracking of serum 25-hydroxyvitamin D during 21 years.European journal of clinical nutrition · 2021Article
- A prospective study into change of vitamin D levels, depression and frailty among depressed older persons.International journal of geriatric psychiatry · 2021Article
- Special Considerations to Improve Clinical Outcomes in Patients with Osteoporosis Undergoing Spine Surgery.International journal of spine surgery · 2021Article
- Trends in Nutritional Biomarkers by Demographic Characteristics Across 14 Years Among US Adults.Frontiers in nutrition · 2021Article
- Seasonal variation and correlation analysis of vitamin D and parathyroid hormone in Hangzhou, Southeast China.Journal of cellular and molecular medicine · 2020Article
- Serum 25-hydroxyvitamin-D and nonalcoholic fatty liver disease: Does race/ethnicity matter? Findings from the MESA cohort.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2020Article
- Serum Levels of 25-Hydroxyvitamin D at Diagnosis Are Not Associated with Overall Survival in Esophageal Adenocarcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Temporal increases in 25-hydroxyvitamin D in midlife women: Longitudinal results from the Study of Women's Health Across the Nation.Clinical endocrinology · 2019Article
- Best Practices for Conducting Observational Research to Assess the Relation between Nutrition and Bone: An International Working Group Summary.Advances in nutrition (Bethesda, Md.) · 2019Article
- Observational
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Authors and funding
16 authors at 9 institutions in 1 country.
Funding
Abstract
Vitamin D is essential for facilitating calcium absorption and preventing increases in parathyroid hormone (PTH), which can augment bone resorption. Our objectives were to examine serum levels of 25-hydroxyvitamin D [25(OH)D] and PTH, and factors related to longitudinal change in a population-based cohort. This is the first longitudinal population-based study looking at PTH and 25(OH)D levels. We analyzed 3896 blood samples from 1896 women and 829 men in the Canadian Multicentre Osteoporosis Study over a 10-year period starting in 1995 to 1997. We fit hierarchical models with all available data and adjusted for season. Over 10 years, vitamin D supplement intake increased by 317 (95% confidence interval [CI] 277 to 359) IU/day in women and by 193 (135 to 252) IU/day in men. Serum 25(OH)D (without adjustment) increased by 9.3 (7.3 to 11.4) nmol/L in women and by 3.5 (0.6 to 6.4) nmol/L in men but increased by 4.7 (2.4 to 7.0) nmol/L in women and by 2.7 (-0.6 to 6.2) nmol/L in men after adjustment for vitamin D supplements. The percentage of participants with 25(OH)D levels <50 nmol/L was 29.7% (26.2 to 33.2) at baseline and 19.8% (18.0 to 21.6) at year 10 follow-up. PTH decreased over 10 years by 7.9 (5.4 to 11.3) pg/mL in women and by 4.6 (0.2 to 9.0) pg/mL in men. Higher 25(OH)D levels were associated with summer, younger age, lower body mass index (BMI), regular physical activity, sun exposure, and higher total calcium intake. Lower PTH levels were associated with younger age and higher 25(OH)D levels in both women and men and with lower BMI and participation in regular physical activity in women only. We have observed concurrent increasing 25(OH)D levels and decreasing PTH levels over 10 years. Secular increases in supplemental vitamin D intake influenced both changes in serum 25(OH)D and PTH levels.
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