ArticleInternational journal of cancer2012
NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Biomarker identification of immune-related genes in pheochromocytoma and paraganglioma.Translational andrology and urology · 2023Article
- Camptothecin, triptolide, and apoptosis inducer kit have differential effects on mitochondria in colorectal carcinoma cells.FEBS open bio · 2022Article
- Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity-impulsivity symptoms in ADHD measured with PET.Molecular psychiatry · 2021Article
- Activation of RAS Signalling is Associated with Altered Cell Adhesion in Phaeochromocytoma.International journal of molecular sciences · 2020Article
- Utilization of HEPES for Enhancing Protein Transfection into Mammalian Cells.Molecular therapy. Methods & clinical development · 2019Article
- Aspirin inhibits the proliferation of hepatoma cells through controlling GLUT1-mediated glucose metabolism.Acta pharmacologica Sinica · 2019Article
- Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis.Cell and tissue research · 2018Review
- Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice.Endocrinology · 2017Article
- Triptolide Inhibits Invasion and Tumorigenesis of Hepatocellular Carcinoma MHCC-97H Cells Through NF-κB Signaling.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Broad targeting of resistance to apoptosis in cancer.Seminars in cancer biology · 2015Review
- Target therapy in metastatic pheochromocytoma: current perspectives and controversies.Oncology reviews · 2014Review
- Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the β1 and β3 but not β2 adrenergic receptors, and induces apoptosis.Pflugers Archiv : European journal of physiology · 2014Article
- Capsaicin induces apoptosis in PC12 cells through ER stress.Oncology reports · 2014Article
- High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma.PloS one · 2014Article
- Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.Neoplasia (New York, N.Y.) · 2013Article
- Current and future therapeutic approaches for metastatic pheochromocytoma and paraganglioma: focus on SDHB tumors.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2013Review
- Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment.Current problems in cancerReview
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are specific types of neuroendocrine tumors that originate in the adrenal medulla or sympathetic/parasympathetic paraganglia, respectively. Although these tumors are intensively studied, a very effective treatment for metastatic PHEO or PGL has not yet been established. Preclinical evaluations of novel therapies for these tumors are very much required. Therefore, in this study we tested the effect of triptolide (TTL), a potent nuclear factor-kappaB (NF-κB) inhibitor, on the cell membrane norepinephrine transporter (NET) system, considered to be the gatekeeper for the radiotherapeutic agent 131I-metaiodobenzylguanidine (131I-MIBG). We measured changes in the mRNA and protein levels of NET and correlated them with proapoptotic factors and metastasis inhibition. The study was performed on three different stable PHEO cell lines. We found that blocking NF-κB with TTL or capsaicin increased both NET mRNA and protein levels. Involvement of NF-κB in the upregulation of NET was verified by mRNA silencing of this site and also by using NF-κB antipeptide. Moreover, in vivo treatment with TTL significantly reduced metastatic burden in an animal model of metastatic PHEO. The present study for the first time shows how NF-κB inhibitors could be successfully used in the treatment of metastatic PHEO/PGL by a significant upregulation of NET to increase the efficacy of 131I-MIBG and by the induction of apoptosis.
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