ArticleJournal of assisted reproduction and genetics2012
A chromosome 19 locus positively influences the number of retrieved oocytes during stimulated cycles in Brazilian women.
Article in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Decoding the genetic architecture of women reproductive aging: multi-omic integration identifies novel loci and mechanistic pathways for precision intervention.BMC genomics · 2025Article
- Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches.Cardiovascular & hematological disorders drug targets · 2024Article
- Genetic Determinants of Premature Menopause in A Mashhad Population Cohort.International journal of fertility & sterility · 2021Article
- Sperm morphological abnormalities visualised at high magnification predict embryonic development, from fertilisation to the blastocyst stage, in couples undergoing ICSI.Journal of assisted reproduction and genetics · 2014Article
- The efficiency of a donor-recipient program using infertile donors' egg cryo-banking: a Brazilian reality.Journal of assisted reproduction and genetics · 2014Article
- The prevalence of sperm with large nuclear vacuoles is a prognostic tool in the prediction of ICSI success.Journal of assisted reproduction and genetics · 2014Article
- Intracytoplasmic morphologically selected sperm injection outcomes: the role of sperm preparation techniques.Journal of assisted reproduction and genetics · 2013Article
- Blastocyst Morphology Holds Clues Concerning The Chromosomal Status of The Embryo.International journal of fertility & sterilityArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
purposeTo evaluate if several genetic loci that are associated with variation in normal menopause age and early menopause can account for a poor response to controlled ovarian stimulation.
methodsA total of 71 patients age ≤35 years old who were undergoing intracytoplasmic sperm injection were genotyped for four genetic variants that are associated with normal variation in menopausal age and early menopause. The patients were divided into two groups based upon treatment response: a poor responder group (PR group, n = 21) and a normal responder group (NR group, n = 50). The genetic variants rs244715, rs9379896, rs4806660 and rs16991615 were analyzed.
resultsThere was no significant difference in the incidence of the genetic variants between the NR and PR group. The risk allele for the chromosome 19 variant (rs4806660) demonstrated a protective effect for a poor ovarian response. The presence of a risk allele was associated with an increased response to COS, which resulted in an elevated number of follicles (Coef: 2.54, P = 0.041) and retrieved oocytes (Coef: 1.41, P = 0.041).
conclusionsThe genetic variants rs244715, rs9379896, rs4806660 and rs16991615 are not risk factors for poor ovarian response in Brazilian women. In contrast, rs4806660 is associated with higher number of follicles and retrieved oocytes. rs4806660 may be associated with an increased response to gonadotrophin stimulation in this population.
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