Evidence map›Paper›PMID 22407576›Full record

ReviewImmunologic research2012

Immune predictors of cancer progression.

Benjamin Toh, Valerie Chew, Xilei Dai, Karen Khoo, Muly Tham, Lu-En Wai, Sandra Hubert, Sumathy Velumani, Liang Zhi, Caleb Huang and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Benjamin TohSingapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #04-06 Immunos, Biopolis, Singapore.
Valerie Chew
Xilei Dai
Karen Khoo
Muly Tham
Lu-En Wai
Sandra Hubert
Sumathy Velumani
Liang Zhi
Caleb Huang
Jean-Pierre Abastado

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune system has multiple, complex, and sometimes opposing roles during cancer progression. While immune-compromised individuals have a higher incidence of cancers, inflammation is also associated with increased risk of disease progression. It is becoming apparent that simple measures of immune responses in the blood are of limited use in cancer. Instead, the importance of the exact identity and functional characteristics of tumor-infiltrating immune cells is increasingly recognized. This realization has led to recent studies that have revealed a critical role for chemokine expression in the tumor microenvironment and suggested a therapeutic potential of manipulating intratumoral expression of chemokines to alter the local immune milieu.

Indexed as

AnimalsBiomarkers, TumorCell MovementChemokinesDisease Models, AnimalDisease ProgressionGene Expression Regulation, NeoplasticHumansImmunityImmunologic SurveillanceMiceMice, TransgenicNeoplasmsPrognosisTumor MicroenvironmentBiomarkers, TumorChemokines

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.