Evidence map›Paper›PMID 22407465›Full record

ReviewAIDS and behavior2013

A proposal for quality standards for measuring medication adherence in research.

Ann Bartley Williams, K Rivet Amico, Carol Bova, Julie A Womack

Registry-linked trialAbstract readReview
In one paragraph

Review in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03302299 (URBAN ARCH), which is not on this map. Cited by 115 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03302299 phase4completednot on this mapstarted 2017, after this paper: background citation

URBAN ARCH (3/5) Uganda Cohort TB Preventive Therapy for HIV-infected Alcohol Users in Uganda: an Evaluation of Safety Tolerability and Adherence

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2021Enrolled302ConditionsTuberculosis, HIV/AIDS, Alcohol AbuseArmsIsoniazid 300 Mg ORAL TABLET, Pyridoxine 25 Mg Oral Tablet
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Methods to assess COPD medications adherence in healthcare databases: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
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  4. Accuracy of measures for antiretroviral adherence in people living with HIV.The Cochrane database of systematic reviews · 2022
    Pooled it
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  8. Assessing medication adherence: options to consider.International journal of clinical pharmacy · 2014
    Pooled it
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ann Bartley WilliamsSchool of Nursing, University of California Los Angeles, Los Angeles, CA, USA. awilliams@sonnet.ucla.edu
K Rivet Amico
Carol Bova
Julie A Womack

Funding

Developing an ART Adherence Intervention in South Central ChinaR34MH083564 · NIMH · YALE UNIVERSITY · PI WILLIAMS, ANN BARTLEY · 2009 to 2011
$671k
HIV Infection and Falls: Epidemiology and Risk AssessmentK01NR013437 · NINR · YALE UNIVERSITY · PI WOMACK, JULIE A · 2012 to 2014
$277k
NIMH NIH HHS R34 MH083564NINR NIH HHS K01 NR013437
6 · The paper itself

Abstract

A decade after widespread recognition that adherence to medication regimens is key to antiretroviral effectiveness, considerable controversy remains regarding a "gold standard" for adherence measurement. Each adherence measurement approach has strengths and weaknesses and each rests on specific assumptions. The range of assumptions regarding adherence measurement and the diversity with which each approach is implemented strongly suggest that the evaluation of a particular measure outside of the context in which it was used (e.g. the study's operational protocol) may result in undeserved confidence or lack of confidence in study results. The purpose of this paper is to propose a set of best practices across commonly used measurement methods. Recommendations regarding what information should be included in published reports regarding how adherence was measured are provided to promote improvement in the quality of measurement of medication adherence in research.

Indexed as

Medication AdherenceAnti-HIV AgentsClinical Trials as TopicDrug MonitoringHIV InfectionsHumansPractice Guidelines as TopicResearch DesignSelf ReportAnti-HIV Agents

Identifiers

PMID22407465
PMCPMC3434290

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.