ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
Procollagen propeptides: serum markers for atrial fibrosis?
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Plasma COL3A1 propeptide as a promising prognostic marker in oral squamous cell carcinoma.Scientific reports · 2026Article
- Diagnostic value of pre-operative serum procollagen type I C-terminal propeptide and procollagen type III N-terminal propeptide levels for post-operative atrial fibrillation in elderly cardiac-surgery patients.Journal of cardiothoracic surgery · 2026Article
- Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review.Biology · 2021Review
- Noninvasive biomarker-based risk stratification for development of new onset atrial fibrillation after coronary artery bypass surgery.International journal of cardiology · 2020Article
- High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus.Translational neuroscience · 2016Article
- Effectiveness of aldosterone antagonists for preventing atrial fibrillation after cardiac surgery in patients with systolic heart failure: a retrospective study.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Novel and nonpharmacologic approaches to cardio-protection in hypertension.Current hypertension reports · 2014Review
- Connective tissue growth factor (CTGF/CCN2): diagnostic and prognostic value in acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Renal sympathetic denervation: applications in hypertension and beyond.Nature reviews. Cardiology · 2013Review
- Circulating Biomarkers Predictive of Postoperative Atrial Fibrillation.Cardiology in reviewReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrosis and its spatial heterogeneity are regarded as a substrate for the perpetuation of atrial arrhythmias. During collagen synthesis and degradation, collagen propeptides and telopeptides are released into the blood. This study tested the hypothesis that serum markers of collagen turnover correlate with atrial fibrosis.
methodsWe prospectively included 28 patients in sinus rhythm undergoing cardiac surgery. Plasma concentrations of the carboxy- and amino-terminal propeptide of procollagen type-I (PICP and PINP) and type-III (PIIINP), and the C-terminal telopeptide of type-I collagen (ICTP) were determined. Interstitial fibrosis of left (n = 10) and right atrial appendages (n = 28) was analyzed histologically.
resultsWe found a correlation between left and right atrial fibrosis (r (s) = 0.79, p < 0.01). Interestingly, the higher the interstitial collagen content, the higher was the spatial heterogeneity of fibrosis (r (s) = 0.90, p < 0.001). However, PICP, PIIINP, and ICTP were not correlated to left or right atrial collagen content, or to the spatial heterogeneity of atrial fibrosis. There was a weak and even negative correlation between the serum PINP concentration and the degree of fibrosis in both the left and the right atrium (r (s) = -0.65 (p = 0.04) and r (s) = -0.42 (p = 0.03), respectively).
conclusionsA high degree of interstitial atrial fibrosis indicates a high degree of spatial heterogeneity of interstitial collagen. Although serum PICP is known to be correlated with ventricular fibrosis, this and other serum markers of collagen turnover (PINP, PIIINP, and ICTP) do not directly reflect atrial fibrosis in patients with severe cardiac disease.
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