ReviewCurrent atherosclerosis reports2012
Molecular pathways regulating macrophage polarization: implications for atherosclerosis.
Review in Current atherosclerosis reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- How Advanced is Nanomedicine to Treat Atherosclerosis? A Comprehensive Review of the Literature.International journal of nanomedicine · 2026Review
- Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Enhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage polarization.Cell death & disease · 2023Article
- The role of immunometabolism in macrophage polarization and its impact on acute lung injury/acute respiratory distress syndrome.Frontiers in immunology · 2023Review
- Current Development of Nano-Drug Delivery to Target Macrophages.Biomedicines · 2022Review
- Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis.Nature reviews. Cardiology · 2022Review
- Macrophage-targeted nanomedicine for the diagnosis and management of atherosclerosis.Frontiers in pharmacology · 2022Review
- Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases.Diseases (Basel, Switzerland) · 2021Review
- Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Circulation research · 2020Article
- Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Review
- A Novel Bivalent Mannosylated Targeting Ligand Displayed on Nanoparticles Selectively Targets Anti-Inflammatory M2 Macrophages.Pharmaceutics · 2020Article
- Macrophage-Based Therapies for Atherosclerosis Management.Journal of immunology research · 2020Review
- The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective.Matrix biology : journal of the International Society for Matrix Biology · 2019Review
- Nature and nurture of tissue-specific macrophage phenotypes.Atherosclerosis · 2019Review
- Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases.Infection and drug resistance · 2019Article
- Transcriptional Regulation of Macrophages Polarization by MicroRNAs.Frontiers in immunology · 2018Review
- Asperlin Inhibits LPS-Evoked Foam Cell Formation and Prevents Atherosclerosis in ApoEMarine drugs · 2017Article
- Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent years have seen a tremendous development of our insight into the biology of atherosclerosis and its acute thrombotic manifestations. Inflammation now takes center stage among traditional risk factors as a decisive factor in cardiovascular risk. Consequently, its assessment and modulation have become key to clinical care and fundamental research alike. Plaque macrophages orchestrate many of the inflammatory processes that occur throughout atherogenesis. These cells are characteristically heterogeneous and adopt diverse activation states in response to micro-environmental triggers. In this review, macrophage-mediated inflammation in atherosclerosis sets the scene for a discussion of the gene regulatory mechanisms that facilitate and shape polarized macrophage phenotypes. When applicable, we consider these factors within the context of atherosclerosis and reflect on opportunities for future application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.