Evidence map›Paper›PMID 22407279›Full record

ArticleChild psychiatry and human development2012

The role of co-occurring disruptive behavior in the clinical presentation of children and adolescents with anxiety in the context of autism spectrum disorders.

Eric A Storch, Elysse B Arnold, Anna M Jones, Chelsea M Ale, Jeffrey J Wood, Jill Ehrenreich-May, Adam B Lewin, P Jane Mutch, Tanya K Murphy

Abstract read
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In one paragraph

Article in Child psychiatry and human development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  11. NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eric A StorchDepartment of Pediatrics, Rothman Center for Neuropsychiatry, University of South Florida, 800 6th Street South, 4th Floor North, Box 7523, St. Petersburg, FL 33701, USA. estorch@health.usf.edu
Elysse B Arnold
Anna M Jones
Chelsea M Ale
Jeffrey J Wood
Jill Ehrenreich-May
Adam B Lewin
P Jane Mutch
Tanya K Murphy

Funding

2/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for AdolescentsR34HD065274 · NICHD · UNIVERSITY OF SOUTH FLORIDA · PI STORCH, ERIC A. · 2009 to 2010
$423k
NICHD NIH HHS 5R34HD065274-02
6 · The paper itself

Abstract

This study explored the impact of disruptive behavior disorder (DBD) comorbidity on theoretically relevant correlates among 87 children and adolescents with autism spectrum disorders (ASD) and clinically significant anxiety. Relative to youth with ASD and anxiety alone, participants with ASD, anxiety, and DBD: (a) presented with significantly more severe anxiety symptoms per clinician-, parent-, and self-report; (b) were more likely to be prescribed antipsychotic medication but were no more likely to receive additional psychosocial and educational interventions; and (c) experienced significantly greater functional impairment and family interference. These results suggest that co-occurring DBD in the context of ASD and anxiety confers greater risk for heightened symptom severity and functional impairment, and may be linked with increased prescription of antipsychotic medication.

Indexed as

Attention Deficit and Disruptive Behavior DisordersChild Development Disorders, PervasiveEarly Intervention, EducationalSocial SupportAdolescentAntipsychotic AgentsAnxietyChildChild BehaviorComorbidityFamily RelationsFemaleHumansMalePsychiatric Status Rating ScalesRisk AssessmentAntipsychotic Agents

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.