ArticleHuman molecular genetics2012
Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
Article in Human molecular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells.Cell death and differentiation · 2026Article
- Article
- Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters.Nucleic acids research · 2024Article
- Long Non-Coding RNAs Differentially Expressed in Swine Fetuses.Animals : an open access journal from MDPI · 2024Article
- A higher dysregulation burden of brain DNA methylation in female patients implicated in the sex bias of Schizophrenia.Molecular psychiatry · 2023Article
- Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction.Molecular human reproduction · 2023Article
- A Higher Dysregulation Burden of Brain DNA Methylation in Female Patients Implicated in the Sex Bias of Schizophrenia.Research square · 2023Article
- Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.Biology of reproduction · 2022Article
- Review
- Effects of the Sex Chromosome Complement, XX, XO, or XY, on the Transcriptome and Development of Mouse Oocytes During Follicular Growth.Frontiers in genetics · 2021Article
- The Use of RNAi Technology to Interfere withBioMed research international · 2020Article
- Review
- Deep Sequencing of Fosmid Clones Indicates Gene Conversion in the Male-Specific Region of the Giant Panda Y Chromosome.Genome biology and evolution · 2018Article
- Genetics of the human Y chromosome and its association with male infertility.Reproductive biology and endocrinology : RB&E · 2018Review
- RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.PLoS genetics · 2017Article
- Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes.Human molecular genetics · 2016Article
- Y-chromosomal genes affecting male fertility: A review.Veterinary world · 2016Review
- Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR.Chromosoma · 2016Article
- A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues.Biology of sex differences · 2016Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Mammalian ZFY genes are located on the Y chromosome, and code putative transcription factors with 12-13 zinc fingers preceded by a large acidic (activating) domain. In mice, there are two genes, Zfy1 and Zfy2, which are expressed mainly in the testis. Their transcription increases in germ cells as they enter meiosis, both are silenced by meiotic sex chromosome inactivation (MSCI) during pachytene, and Zfy2 is strongly reactivated later in spermatids. Recently, we have shown that mouse Zfy2, but not Zfy1, is involved in triggering the apoptotic elimination of specific types of sex chromosomally aberrant spermatocytes. In humans, there is a single widely transcribed ZFY gene, and there is no evidence for a specific role in the testis. Here, we characterize ZFY transcription during spermatogenesis in mice and humans. In mice, we define a variety of Zfy transcripts, among which is a Zfy2 transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain, which predominates prior to MSCI. In humans, we have identified a major testis-specific ZFY transcript that encodes a protein with the same short acidic domain. This represents the first evidence that ZFY has a conserved function during human spermatogenesis. We further show that, in contrast to the full acidic domain, the short domain does not activate transcription in yeast, and we hypothesize that this explains the functional difference observed between Zfy1 and Zfy2 during mouse meiosis.
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