ArticleThe American journal of psychiatry2012
Mineralocorticoid receptor Iso/Val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdala reactivity.
Article in The American journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 167 citations in OpenAlex.
- Mineralocorticoid receptor stimulation improves cognitive function and decreases cortisol secretion in depressed patients and healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- The Association Between Childhood Trauma and Selective Serotonin Reuptake Inhibitor Treatment Outcomes in Adult Patients With Major Depressive Disorder.Psychiatry investigation · 2025Article
- Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation During Childhood and Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma.Neuroimage. Reports · 2024Article
- The cortisol switch between vulnerability and resilience.Molecular psychiatry · 2024Review
- Effects of environmental and genetic interactions on job burnout in coal miners: interactions between occupational stress, coping styles, andFrontiers in public health · 2023Article
- Impact of Mineralocorticoid Receptor GeneInternational journal of environmental research and public health · 2022Article
- Brain mineralocorticoid receptor in health and disease: From molecular signalling to cognitive and emotional function.British journal of pharmacology · 2022Article
- Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy.Neurobiology of stress · 2022Article
- Neuroanatomical changes associated with conduct disorder in boys: influence of childhood maltreatment.European child & adolescent psychiatry · 2022Article
- Novel Pharmacological Approaches to the Treatment of Depression.Life (Basel, Switzerland) · 2022Review
- Childhood maltreatment and within-person associations between cortisol and affective experience.Stress (Amsterdam, Netherlands) · 2021Article
- Stress and Learning in Pupils: Neuroscience Evidence and its Relevance for Teachers.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2021Review
- The Relationship Between Childhood Emotional Abuse and Processing of Emotional Facial Expressions in Healthy Young Men: Event-Related Potential and Behavioral Evidence.Frontiers in psychology · 2021Article
- Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation.Development and psychopathology · 2020Article
- The relevance of a rodent cohort in the Consortium on Individual Development.Developmental cognitive neuroscience · 2020Article
- Childhood maltreatment experiences are associated with altered diffusion in occipito-temporal white matter pathways.Brain and behavior · 2020Article
- The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.The American journal of psychiatry · 2020Review
- Association of Prepubertal and Postpubertal Exposure to Childhood Maltreatment With Adult Amygdala Function.JAMA psychiatry · 2019Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveThe amygdala is especially reactive to threatening stimuli, and the degree of reactivity predicts individual differences in the expression of depression and anxiety. Emerging research suggests that emotional neglect during childhood as well as hypercortisolemia may lead to heightened threat-related amygdala reactivity. This raises the possibility that genetic variation affecting hypothalamic-pituitary-adrenal (HPA) axis function contributes to individual differences in amygdala reactivity, both independently and as a function of childhood emotional neglect.
methodThis study assessed whether the mineralocorticoid receptor iso/val polymorphism (rs5522), a functional genetic variant affecting HPA axis function, influenced threat-related amygdala reactivity in 279 individuals in late childhood and early adolescence. The study also explored the extent to which any effects of the genotype on amygdala reactivity were contingent upon previous childhood emotional neglect.
resultsPrior childhood emotional neglect and the val allele were associated with greater amygdala reactivity. Moreover, a significant genotype-by-emotional neglect interaction was observed whereby greater amygdala reactivity in val allele carriers was independent of previous childhood emotional neglect, while greater reactivity in iso homozygotes was revealed only in the context of a history of elevated emotional neglect. At relatively low levels of previous emotional neglect, val carriers had heightened amygdala reactivity relative to iso homozygotes.
conclusionsThese results suggest that relatively greater amygdala reactivity may represent a biological mechanism through which childhood adversity and functional genetic variation in HPA axis responsiveness to stress may mediate risk for psychopathology.
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