ArticleMedical microbiology and immunology2012
Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus.
Article in Medical microbiology and immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Burden and Characteristics of Respiratory Syncytial Virus-Associated Bronchiolitis in Hospitalized Infants in Italy: A Systematic Review.Immunity, inflammation and disease · 2026Pooled it
- Trial
- Utility of Lung Ultrasound Assessment in Infants with Acute Bronchiolitis: An Observational Study - Correspondence.Indian journal of pediatrics · 2026Article
- Utility of Lung Ultrasound Assessment in Infants with Acute Bronchiolitis: An Observational Study.Indian journal of pediatrics · 2026Observational
- Reliability of RSV Antigen Diagnostic Tests in the Presence of Nirsevimab.The Pediatric infectious disease journal · 2026Article
- Viral Burden of Respiratory Syncytial Virus and Viral Coinfections as Factors Regulating Paediatric Disease Severity.Viruses · 2025Article
- Clinical Outcomes of Acutely Ill Children According to Cycle Threshold Values of Respiratory Viruses Detected by Multiplex PCR Testing.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Respiratory Syncytial Virus-Load Kinetics and Clinical Course of Acute Bronchiolitis in Hospitalized Infants: Interim Results and Review of the Literature.Pathogens (Basel, Switzerland) · 2023Article
- An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children.Frontiers in pediatrics · 2022Article
- The Association between Weather Conditions and Admissions to the Paediatric Intensive Care Unit for Respiratory Syncytial Virus Bronchiolitis.Pathogens (Basel, Switzerland) · 2021Article
- Differential interferon gene expression in bronchiolitis caused by respiratory syncytial virus-A genotype ON1.Medical microbiology and immunology · 2020Article
- The Relationship Between Chest Imaging Findings and the Viral Load of COVID-19.Frontiers in medicine · 2020Article
- Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That.Frontiers in pediatrics · 2020Review
- Role of Type I Interferon (IFN) in the Respiratory Syncytial Virus (RSV) Immune Response and Disease Severity.Frontiers in immunology · 2019Review
- Predictors of prolonged length of hospital stay for infants with bronchiolitis.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2018Article
- Differential Responses by Human Respiratory Epithelial Cell Lines to Respiratory Syncytial Virus Reflect Distinct Patterns of Infection Control.Journal of virology · 2018Article
- Understanding Viral dsRNA-Mediated Innate Immune Responses at the Cellular Level Using a Rainbow Trout Model.Frontiers in immunology · 2018Article
- Respiratory Syncytial Virus Genotypes, Host Immune Profiles, and Disease Severity in Young Children Hospitalized With Bronchiolitis.The Journal of infectious diseases · 2017Observational
- Etiology and clinical features of viral bronchiolitis in infancy.World journal of pediatrics : WJP · 2017Review
- Pitfalls in interpretation of CT-values of RT-PCR in children with acute respiratory tract infections.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between viral load, disease severity and antiviral immune activation in infants suffering from respiratory syncytial virus (RSV)-associated bronchiolitis has not been well identified. The main objective of this study was to determine the existence of a correlation between RSV load and disease severity and also between different clinical markers and mRNA levels of the interferon stimulated gene (ISG)56 in infants hospitalized for bronchiolitis. We also evaluated whether viral load tended to be persistent over the course of the RSV infection. The levels of RSV-RNA were quantified in nasopharyngeal washings, collected from 132 infants infected with RSV as a single (90.15%) or as a dual infection with other respiratory viruses (9.85%). Results indicated that viral load was positively related to the clinical severity of bronchiolitis, the length of hospital stay, the levels of glycemia and the relative gene expression of ISG56, whereas an inverse correlation was observed with the levels of hemoglobin. We also found that the RSV load significantly decreased between the first and second nasopharingeal washings sample in most subjects. These results suggest that infants with high RSV load on hospital admission are more likely to have both more severe bronchiolitis and a higher airway activation of antiviral immune response.
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