ReviewCurrent opinion in hematology2012
Recent advances in vascular development.
Review in Current opinion in hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular biomarkers in cardiac hypertrophy.Journal of cellular and molecular medicine · 2019Review
- Rhamnazin attenuates inflammation and inhibits alkali burn-induced corneal neovascularization in rats.RSC advances · 2018Article
- Laminar flow downregulates Notch activity to promote lymphatic sprouting.The Journal of clinical investigation · 2017Article
- Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma.International journal of biological sciences · 2017Article
- Association between miR-181b and PKG 1 in myocardial hypertrophy and its clinical implications.Experimental and therapeutic medicine · 2015Article
- Modulation of endothelial cell phenotype by physical activity: impact on obesity-related endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2015Review
- Notch signal integration in the vasculature during remodeling.Vascular pharmacology · 2014Review
- Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.Cell research · 2014Article
- Transcriptional changes in organoculture of full-thickness human skin following topical application of all-trans retinoic acid.International journal of cosmetic science · 2014Article
- Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis.Journal of biomedical research · 2014Review
- UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development.Development (Cambridge, England) · 2013Article
- Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation.The Journal of experimental medicine · 2013Article
- Tight control - decision-making during T cell-vascular endothelial cell interaction.Frontiers in immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThis review offers a concise summary of the most recent experimental advances in vascular development using the mouse as a model organism. RECENT
findingsRecent mouse studies have revealed a spread of phenotypic diversity between endothelia of distinct developmental origins and organs. For example, expression of unique transcription factors distinguishes hemogenic from nonhemogenic endothelium within the same vessel. Vasculature of the brain is particularly susceptible to endothelial malformations due to combinatorial germline and somatic mutations; surprisingly these mutations can afflict the endothelium by either cell autonomous or paracrine effects. Mutant mice have been used to understand how multiple signaling pathways integrate and refine cellular responses. In particular, we learned how VEGFR3 regulates Notch signaling and EphrinB2 coordinates VEGFR2 responses. The regulation of Prox1 by miR181 highlighted the contribution of microRNAs in the induction of lymphatic endothelium. Information gained on heterotypic interactions has further clarified the influence of blood vessels on the morphogenesis of parenchyma and contributed to our understanding of organ-specific endothelial differentiation. Finally, mouse models have uncovered endothelial cell polarity as a keystone for successful vascular lumenization. SUMMARY: Our understanding of the process of vascular development has gained significant refinement in the last two years and has clarified the origin of several disorders rooted in development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.