ArticleNature genetics2012
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing.
Article in Nature genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
175 citing papers in PubMed, 1 synthesis or guideline pooled it, 312 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men.Emerging infectious diseases · 2016Pooled it
- Diversity of Chlamydia trachomatis in Trachoma-Hyperendemic Communities Treated With Azithromycin.American journal of epidemiology · 2018Trial
- Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.Antimicrobial agents and chemotherapy · 2015Trial
- A new core-genome MLST approach for Chlamydia trachomatis genomic surveillance and research.Nature communications · 2026Article
- Genome-wide association studies ofInfection and immunity · 2026Article
- Putative azithromycin resistance mutations inAntimicrobial agents and chemotherapy · 2026Article
- Comparative transcriptomic profiling of human conjunctival epithelial cells and macrophages in response toFrontiers in cellular and infection microbiology · 2026Article
- Pathogenicity and virulence ofVirulence · 2025Review
- Population-based concordance ofMicrobiology spectrum · 2025Article
- Evolutionary dynamics in the genome of ocularMicrobial genomics · 2025Article
- Whole-genome automated assembly pipeline forNAR genomics and bioinformatics · 2025Article
- Biodegradation of sodium selenite by a highly tolerant strainCurrent research in microbial sciences · 2025Article
- Article
- Genetic Homogeneity ofPathogens (Basel, Switzerland) · 2024Article
- Insights into Chlamydia Development and Host Cells Response.Microorganisms · 2024Review
- Unravelling Chlamydia trachomatis diversity in Amhara, Ethiopia: MLVA-ompA sequencing as a molecular typing tool for trachoma.PLoS neglected tropical diseases · 2024Article
- Article
- ReporType: A Flexible Bioinformatics Tool for Targeted Loci Screening and Typing of Infectious Agents.International journal of molecular sciences · 2024Article
- Genomic insights into local-scale evolution of ocularMicrobial genomics · 2024Article
- Zoonotic and other veterinary chlamydiae - an update, the role of the plasmid and plasmid-mediated transformation.Pathogens and disease · 2024Review
115 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 14 institutions in 7 countries.
Funding
Abstract
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting phylogenetic structure using ompA, which is traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks any true relationships present. We show that in many instances, ompA is a chimera that can be exchanged in part or as a whole both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, which is another key diagnostic target. We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.