ArticleActa biomaterialia2012
Formulation and characterization of poloxamine-based hydrogels as tissue sealants.
Article in Acta biomaterialia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Preparation of Hydrogel by Crosslinking and Multi-Dimensional Applications.Gels (Basel, Switzerland) · 2025Review
- Conceptualization and Preliminary Characterization of Poloxamer-Based Hydrogels for Biomedical Applications.Bioconjugate chemistry · 2025Article
- Stearyl amine tailored spanlastics embedded within tetronicDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025Article
- Construction of a corresponding empirical model to bridge thermal properties and synthesis of thermoresponsive poloxamines.Designed monomers and polymers · 2024Article
- A Novel Bio-Adhesive Mesh System for Medical Implant Applications: In Vivo Assessment in a Rabbit Model.Gels (Basel, Switzerland) · 2023Article
- Hydroelastomers: soft, tough, highly swelling composites.Soft matter · 2022Article
- Correlating the mass and mechanical property changes during the degradation of PEG-based adhesive.Journal of applied polymer science · 2020Article
- Engineering a naturally-derived adhesive and conductive cardiopatch.Biomaterials · 2019Article
- Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system.Acta pharmaceutica Sinica. B · 2017Article
- Poloxamine/fibrin hybrid hydrogels for non-viral gene delivery.Journal of tissue engineering and regenerative medicine · 2017Article
- Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine.International journal of molecular sciences · 2015Review
- Design of Thiol- and Light-sensitive Degradable Hydrogels using Michael-type Addition Reactions.Polymer chemistry · 2015Article
- Mechanical characterization of a bifunctional Tetronic hydrogel adhesive for soft tissues.Journal of biomedical materials research. Part A · 2015Article
- Tetronic(®)-based composite hydrogel scaffolds seeded with rat bladder smooth muscle cells for urinary bladder tissue engineering applications.Journal of biomaterials science. Polymer edition · 2015Article
- Clinical applications of surgical adhesives and sealants.Critical reviews in biomedical engineering · 2014Review
- Mechanically robust, negative-swelling, mussel-inspired tissue adhesives.Advanced healthcare materials · 2013Article
Corrections and comments
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3 authors.
Funding
Abstract
In situ cross linkable polyethylene glycol (PEG)-based polymers play an increasing role in surgical practice as sealants that provide a barrier to fluid/gas leakage and adhesion formation. This study investigated the gelation behavior and physical properties of hydrogels formed from homogeneous and blended solutions of two acrylated poloxamines (Tetronics® T1107 and T904) of various molecular weights and hydrophilic/lipophilic balances relative to a PEG control. Hydrogels were formed by reverse thermal gelation at physiological temperature (T1107-containing formulations) and covalent crosslinking by Michael-type addition with dithiothreitol. All poloxamine-based hydrogels exhibited thermosensitive behavior and achieved significantly reduced swelling, increased tensile properties and increased tissue bond strength relative to the PEG hydrogel at physiological temperature. Swelling and tensile properties of all poloxamine-based hydrogels were significantly greater at 37°C relative to 4°C, suggesting that their improved physical properties derive from cooperative crosslinking by both noncovalent and covalent mechanisms. Poloxamine-based hydrogels were cytocompatible and underwent hydrolytic degradation over 2-5weeks, depending on their T1107/T904 composition. In conclusion, select poloxamine-based hydrogels possess a number of properties potentially beneficial to tissue sealant applications, including a substantial increase in viscosity between room/physiological temperatures, resistance to cell adhesion and maintenance of a stable volume during equilibration.
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