ReviewPhysiology & behavior2012
Oxytocin receptor and Mecp2 308/Y knockout mice exhibit altered expression of autism-related social behaviors.
Review in Physiology & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- An overview of oxytocin integrative mechanisms in autism spectrum disorder.Discover mental health · 2025Review
- LinkedbioRxiv : the preprint server for biology · 2025Article
- Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs.Translational psychiatry · 2025Article
- Review
- Article
- Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models.Current research in neurobiology · 2021Review
- Effects of PMParticle and fibre toxicology · 2020Article
- Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.Neurobiology of disease · 2018Article
- Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neonatal Oxytocin Treatment Ameliorates Autistic-Like Behaviors and Oxytocin Deficiency in Valproic Acid-Induced Rat Model of Autism.Frontiers in cellular neuroscience · 2018Article
- Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons.Autism research : official journal of the International Society for Autism Research · 2016Article
- Autism-Like Behavior in BTBR Mice Is Improved by Electroconvulsive Therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Article
- A Role for Oxytocin in the Etiology and Treatment of Schizophrenia.Frontiers in endocrinology · 2015Review
- Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas.Autism research : official journal of the International Society for Autism Research · 2014Article
- Sociosexual and communication deficits after traumatic injury to the developing murine brain.PloS one · 2014Article
- The role of behavior in translational models for psychopathology: functionality and dysfunctional behaviors.Neuroscience and biobehavioral reviews · 2013Review
- Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders.American journal of human genetics · 2012Article
- Beyond WidespreadAutism-open access · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The development of tasks measuring behaviors specific to the three major symptom categories for autism makes it possible to differentiate mouse models of autism spectrum disorders (ASD) in terms of changes in these specific categories. Prior studies indicate that BTBR T+tf/J mice, the strain that has been evaluated most extensively, show autism-relevant changes in all three symptom categories; reciprocal social interactions; communication; and repetitive, ritualized behaviors. This report reviews the behaviors of oxytocin receptor (Oxtr) and Mecp2(308/Y) wild-type (WT) and knockout (KO) mice, in a number of tests specifically designed to provide information on behaviors that may show functional parallels to the core symptoms of ASD. Oxtr KO mice show robust decreases in reciprocal social interactions, and reduced levels of communication, but no changes in repetitive, ritualized behaviors; whereas Mecp2(308/Y) KO mice show a slight but consistent enhancement of social behavior and communication, and no changes in repetitive, ritualized behaviors. This data base, although small, strongly indicates that mouse models can sort the diagnostic symptoms of autism, and suggests that biological and physiological analyses of these strains may be capable of providing differential information on the brain systems involved in particular symptoms of this disorder. Profiles of behavioral changes in other mouse models of ASD should provide additional specificity in the search for biomarkers associated with particular ASD symptoms and symptom clusters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.