ReviewPhysiology & behavior2012
The gut-brain dopamine axis: a regulatory system for caloric intake.
Review in Physiology & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- When does post-ingestive dopamine signaling occur in humans?bioRxiv : the preprint server for biology · 2026Article
- Hyperdopaminergic States Bias Explorations-Exploitation Trade-Off in Foraging and Impair Survival.The European journal of neuroscience · 2026Article
- Applicability of targeted metabolomics for the prediction of feed efficiency groups and metrics in dairy sheep.JDS communications · 2026Article
- Neural mechanisms linking Western diet consumption and cognitive impairment: a role for the vagus nerve.Clinical science (London, England : 1979) · 2026Review
- Right vagus nerve stimulation promotes motor cortical plasticity.Scientific reports · 2026Article
- Glucagon-like Peptide-1 and Dual GIP/GLP-1 Receptor Agonists in Brain: Exploring the Expanding Role and Safety in Neuropsychiatry.International journal of molecular sciences · 2026Review
- The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events.Science advances · 2026Article
- Dopaminergic signalling in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- Investigating the modulation of gastric sensations and disposition toward food with taVNS.Psychophysiology · 2025Article
- The consequences of ultra-processed foods on brain development during prenatal, adolescent and adult stages.Frontiers in public health · 2025Review
- The role of the brain renin-angiotensin system in Parkinson´s disease.Translational neurodegeneration · 2024Review
- Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating.Cell metabolism · 2024Article
- Levodopa attenuates the feed intake reduction caused by ergot alkaloids in cattle.Journal of animal science · 2024Article
- Standard rodent diets differentially impact alcohol consumption, preference, and gut microbiome diversity.Frontiers in neuroscience · 2024Article
- Effects of Fructose and Palmitic Acid on Gene Expression inInternational journal of molecular sciences · 2023Article
- Identification of a neural development gene expression signature in colon cancer stem cells reveals a role foriScience · 2022Article
- Supramolecule self-assembly synthesis of amyloid phenylalanine-Cu fibrils with laccase-like activity and their application for dopamine determination.Mikrochimica acta · 2022Article
- Acute Effects of Different Electroacupuncture Point Combinations to Modulate the Gut-Brain Axis in the Minipig Model.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- How we decide what to eat: Toward an interdisciplinary model of gut-brain interactions.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study.Brain sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Post-ingestive factors are known to strongly modulate feeding behavior by providing feedback signals to the central nervous system on the current physiological state of the organism. Of particular interest is the identification of the physiological pathways that permit the brain to sense post-ingestive signals. We will review recent evidence supporting the concept that direct stimulation of the gastrointestinal tract with nutrients induces release of the catecholamine neurotransmitter dopamine. In addition, changes in dopamine efflux produced by direct stimulation of the gastrointestinal tract were found to reflect the caloric load of the infusates, suggesting that dopamine signaling may function as a central caloric sensor that mediates adjustments in intake according to the caloric density of a meal. Consistent with the above, blockade of dopamine signaling disrupts flavor-nutrient associations and impairs the regulatory capacity to maintain constant caloric intake during intra-gastric feeding. Future research must determine the exact pathways linking gut nutrient administration to dopamine efflux. Current evidence points to parallel contributions by pre- and post-absorptive pathways, indicating that dopamine systems constitute a site of convergence through which distinct physiological signals can exert control over ingestive behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.