ReviewBiochimica et biophysica acta2012
Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription.
Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- What makes genes burst.Trends in cell biology · 2026Review
- Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens.Molecular cell · 2025Article
- Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens.bioRxiv : the preprint server for biology · 2024Article
- Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures.Nucleic acids research · 2023Article
- The BORDER family of negative transcription elongation factors regulates flowering time in Arabidopsis.Current biology : CB · 2021Article
- A unified view of the sequence and functional organization of the human RNA polymerase II promoter.Nucleic acids research · 2020Article
- TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ.Nucleic acids research · 2020Article
- BORDER proteins protect expression of neighboring genes by promoting 3' Pol II pausing in plants.Nature communications · 2019Article
- Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation.Retrovirology · 2019Article
- CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.Molecular cell · 2017Article
- Linking Core Promoter Classes to Circadian Transcription.PLoS genetics · 2016Article
- Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters.PLoS genetics · 2016Article
- In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver.Cellular and molecular life sciences : CMLS · 2014Review
- Time resolved DNA occupancy dynamics during the respiratory oscillation uncover a global reset point in the yeast growth program.Microbial cell (Graz, Austria) · 2014Article
- Epigenetic control of immunity.Cold Spring Harbor perspectives in biology · 2014Article
- RNA polymerase II transcription elongation control.Chemical reviews · 2013Review
- The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.Molecular cell · 2013Article
- Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index.Bioinformatics (Oxford, England) · 2013Article
- Pleiohomeotic interacts with the core transcription elongation factor Spt5 to regulate gene expression in Drosophila.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Altering gene expression in response to stimuli is a pivotal mechanism through which organisms execute developmental programs and respond to changes in their environment. Packaging of promoter DNA into chromatin can greatly impact the ability of RNA polymerase II to access and transcribe a gene. Promoter chromatin environments thus play a central role in establishing transcriptional output appropriate for specific environmental conditions or developmental states. Recent genomic studies have illuminated general principles of chromatin organization and deepened our understanding of how promoter sequence and nucleosome architecture may impact gene expression. Concurrently, pausing of polymerase during early elongation has been recognized as an important event influencing transcription of genes within stimulus-responsive networks. Promoters regulated by pausing are now recognized to possess a distinct chromatin architecture that may facilitate the plasticity of gene expression in response to signaling events. Here we review advances in understanding chromatin and pausing, and explore how coupling Pol II pausing to distinct promoter architectures may help organisms achieve flexible yet precise transcriptional control. This article is part of a Special Issue entitled: Chromatin in time and space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.