Trial reportJournal of substance abuse treatment2012
Comorbid depression and substance use disorder: longitudinal associations between symptoms in a controlled trial.
Trial report in Journal of substance abuse treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00018655 (Integrated Intervention for Substance Abusers With Depressive Disorders), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrated Intervention for Substance Abusers With Depressive Disorders
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health-promotion interventions targeting multiple behaviors: A meta-analytic review of general and behavior-specific processes of change.Psychological bulletin · 2024Pooled it
- Psychological interventions for co-occurring depression and substance use disorders.The Cochrane database of systematic reviews · 2019Pooled it
- Extended-release injection vs sublingual buprenorphine for illicit opioid use in pregnant patients with depression and/or anxiety.Drug and alcohol dependence · 2026Article
- Modeling Concurrent Hedonic Disruption During Excessive Drinking and Abstinence-Related Negative Affect in a Novel Selectively Bred Mouse Line: The Crossed High Alcohol Preferring X High Drinking in the Dark (cHAPxHDID) Mice.Alcohol, clinical & experimental research · 2026Article
- Healthcare utilization among adults with co-occurring substance use and mental health disorders (2018-2023): A study based on All of Us program.medRxiv : the preprint server for health sciences · 2026Article
- Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review.Alcohol, clinical & experimental research · 2025Review
- Psychedelic Research for Alcohol Use Disorder with Comorbid Major Depressive Disorder: An Unmet Need.Current psychiatry reports · 2024Review
- Article
- Prevalence of stressful life events and associations with symptoms of depression, anxiety, and post-traumatic stress disorder among people entering care for HIV in Cameroon.Journal of affective disorders · 2022Article
- Are Comorbid Disorders Associated with Changes in Gambling Activity? A Longitudinal Study of Younger and Older Subjects with DSM-IV Pathological Gambling.Journal of gambling studies · 2021Article
- An Exploratory Analysis of Predictors of Course in Older and Younger Adults with Pathological Gambling: A Non-Treatment Sample.Journal of gambling studies · 2021Article
- Perception of Unmet Need after Seeking Treatment for a Past Year Major Depressive Episode: Results from the 2018 National Survey of Drug Use and Health.The Psychiatric quarterly · 2021Article
- Social Learning and Addiction.Behavioural brain research · 2021Review
- Detecting Suicide and Self-Harm Discussions Among Opioid Substance Users on Instagram Using Machine Learning.Frontiers in psychiatry · 2021Article
- Individuals at Risk of Exercise Addiction Have Higher Scores for Depression, ADHD, and Childhood Trauma.Frontiers in sports and active living · 2021Article
- Cannabis Use, Cannabis Use Disorder, and Comorbid Psychiatric Illness: A Narrative Review.Journal of clinical medicine · 2020Review
- The Effectiveness ofThe Yale journal of biology and medicine · 2020Article
- Relation between cognitive and behavioral strategies and future change in common mental health problems across 18 years.Journal of abnormal psychology · 2019Article
- Substance type moderates the longitudinal association between depression and substance use from pre-treatment through a 1-year follow-up.Drug and alcohol dependence · 2019Article
- Changes in depression mediate the effects of AA attendance on alcohol use outcomes.The American journal of drug and alcohol abuse · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This study examined the longitudinal association between substance use and depressive symptoms in veterans receiving outpatient treatment for comorbid substance use disorder and major depression. Veterans (N = 237, mean age = 48.2 years, 90% male, 70% Caucasian) received either 6 months of group integrated cognitive-behavioral therapy or twelve-step facilitation. Hamilton Depression Rating Scale scores and percent days using any substance were assessed every 3 months up to 1 year posttreatment. Greater substance use predicted time-varying elevations in depression above individual patterns of change in depression. Moreover, change in depressive symptoms was associated with change in both the likelihood of any substance use and the frequency of use during the treatment and follow-up periods. Changes in these symptoms appear to be linked, such that individuals with greater reductions in substance use have greater reductions in depressive symptoms (and vice versa).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.