ReviewExperimental cell research2012
WNK kinases and the kidney.
Review in Experimental cell research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- The Story of Aldosterone Escape.Journal of the American Society of Nephrology : JASN · 2026Review
- The Role of Chloride in Cardiorenal Syndrome: A Practical Review.Journal of clinical medicine · 2025Review
- UBR5 is a novel regulator of WNK1 stability.American journal of physiology. Cell physiology · 2022Article
- Genomic Association of Single Nucleotide Polymorphisms with Blood Pressure Response to Hydrochlorothiazide among South African Adults with Hypertension.Journal of personalized medicine · 2020Article
- Small-molecule WNK inhibition regulates cardiovascular and renal function.Nature chemical biology · 2016Article
- New perspective of ClC-Kb/2 Cl- channel physiology in the distal renal tubule.American journal of physiology. Renal physiology · 2016Review
- American Society of Nephrology Quiz and Questionnaire 2015: Electrolytes and Acid-Base Disorders.Clinical journal of the American Society of Nephrology : CJASN · 2016Article
- Pathophysiology and clinical presentations of salt-losing tubulopathies.Pediatric nephrology (Berlin, Germany) · 2016Review
- Renal acid-base regulation: new insights from animal models.Pflugers Archiv : European journal of physiology · 2015Review
- Changes in urinary excretion of water and sodium transporters during amiloride and bendroflumethiazide treatment.World journal of nephrology · 2015Article
- Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport.BioMed research international · 2015Review
- Regulatory roles of nitric oxide and angiotensin II on renal tubular transport.World journal of nephrology · 2014Review
- Mechanism and synergism in epithelial fluid and electrolyte secretion.Pflugers Archiv : European journal of physiology · 2014Review
- The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.Pflugers Archiv : European journal of physiology · 2014Review
- PharmGKB summary: Diuretics pathway, pharmacodynamics.Pharmacogenetics and genomics · 2013Article
- Direct activation of ENaC by angiotensin II: recent advances and new insights.Current hypertension reports · 2013Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
In the kidney, the renal tubule plays a major role in maintaining fluid and electrolyte balance. This balance is achieved by an interplay between various hormones and nerves that signal changes throughout the body and transfer these signals to transport proteins. Increased or reduced activity of these transporters helps to restore homeostasis, but can also contribute to disease (e.g. sodium retention in hypertension). In recent years, it has become clear that the signal transfer to transporters is largely mediated by kinases. Among these, WNK kinases (With No lysine=K) stand out, because they regulate the major sodium and potassium transporters in the distal nephron. Moreover, mutations in genes encoding WNK kinases result in an inherited form of salt-sensitive hypertension with hyperkalemia, illustrating their important role in sodium, potassium, and blood pressure regulation. More recently, WNK kinases were found to play a role in acquired forms of hypertension as well. Together, the evolving insight in the kinase regulation of ion transport is providing new insights in the longstanding question how salt and blood pressure are related. Here, we review the current models of how WNK kinases regulate the various transport proteins and which roles they play in health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.