ArticleCurrent biology : CB2012
Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 75 citations in OpenAlex.
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- FOXM1 is critical for the fitness recovery of chromosomally unstable cells.Cell death & disease · 2023Article
- The Role of Non-Coding RNAs in Chromosomal Instability in Cancer.The Journal of pharmacology and experimental therapeutics · 2023Review
- BUB3, beyond the Simple Role of Partner.Pharmaceutics · 2022Review
- The Interplay of Cohesin and RNA Processing Factors: The Impact of Their Alterations on Genome Stability.International journal of molecular sciences · 2022Review
- Clinical Applications of Aneuploidies in Evolution of NSCLC Patients: Current Status and Application Prospect.OncoTargets and therapy · 2022Review
- Aneuploidy as a promoter and suppressor of malignant growth.Nature reviews. Cancer · 2021Review
- p53 Is Not Required for High CIN to Induce Tumor Suppression.Molecular cancer research : MCR · 2021Article
- Chromosomal Instability in Tumor Initiation and Development.Cancer research · 2019Review
- Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability.Molecular biology of the cell · 2018Article
- The impact of mitotic errors on cell proliferation and tumorigenesis.Genes & development · 2018Review
- Dissecting the role of the tubulin code in mitosis.Methods in cell biology · 2018Article
- The association between MAD2 and prognosis in cancer: a systematic review and meta-analyses.Oncotarget · 2017Article
- Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.Scientific reports · 2017Article
- A Dynamical Model for Activating and Silencing the Mitotic Checkpoint.Scientific reports · 2017Article
- Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.Cell reports · 2017Article
- Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size.The Journal of cell biology · 2017Article
- The Role of Aneuploidy in Cancer Evolution.Cold Spring Harbor perspectives in medicine · 2017Review
- Regulation of AURORA B function by mitotic checkpoint protein MAD2.Cell cycle (Georgetown, Tex.) · 2016Article
- Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.Cell reports · 2016Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Faithful chromosome segregation is required for cell and organism viability and relies on both the mitotic checkpoint and the machinery that corrects kinetochore-microtubule (k-MT) attachment errors. Most solid tumors have aneuploid karyotypes and many missegregate chromosomes at high rates in a phenomenon called chromosomal instability (CIN). Mad2 is essential for mitotic checkpoint function and is frequently overexpressed in human tumors that are CIN. For unknown reasons, cells overexpressing Mad2 display high rates of lagging chromosomes. Here, we explore this phenomenon and show that k-MT attachments are hyperstabilized by Mad2 overexpression and that this undermines the efficiency of correction of k-MT attachment errors. Mad2 affects k-MT attachment stability independently of the mitotic checkpoint because k-MT attachments are unaltered upon Mad1 depletion and Mad2 overexpression hyperstabilizes k-MT attachments in Mad1-deficient cells. Mad2 mediates these effects with Cdc20 by altering the centromeric localization and activity of Aurora B kinase, a known regulator of k-MT attachment stability. These data reveal a new function for Mad2 to stabilize k-MT attachments independent of the checkpoint and explain why Mad2 overexpression increases chromosome missegregation to cause chromosomal instability in human tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.