ArticleSchizophrenia research2012
White matter integrity, language, and childhood onset schizophrenia.
Article in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- [White matter microstructural disturbance and its relationship with cognitive function in schizophrenia with comorbidity of metabolic syndrome].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder.Psychological medicine · 2023Article
- The correlation between white matter integrity and pragmatic language processing in first episode schizophrenia.Brain imaging and behavior · 2021Article
- Brain free water alterations in first-episode psychosis: a longitudinal analysis of diagnosis, course of illness, and medication effects.Psychological medicine · 2021Article
- Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD.Birth defects research · 2019Article
- Gray Matter Microstructural Abnormalities and Working Memory Deficits in Individuals with Schizophrenia.Psychiatry investigation · 2019Article
- Investigation of superior longitudinal fasciculus fiber complexity in recent onset psychosis.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- White matter correlates of the disorganized speech dimension in schizophrenia.European archives of psychiatry and clinical neuroscience · 2018Article
- Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study.Schizophrenia research · 2017Article
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophrenia research · 2016Review
- Development of human white matter fiber pathways: From newborn to adult ages.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Article
- Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect.Journal of child psychology and psychiatry, and allied disciplines · 2016Review
- The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates.Journal of child neurology · 2015Article
- Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression.Translational psychiatry · 2014Article
- A review of structural neuroimaging in schizophrenia: from connectivity to connectomics.Frontiers in human neuroscience · 2014Review
- A comparison of neuroimaging findings in childhood onset schizophrenia and autism spectrum disorder: a review of the literature.Frontiers in psychiatry · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe heterogeneity of symptoms and cognitive deficits in schizophrenia can be explained by abnormal connectivity between brain regions. Childhood-onset schizophrenia (COS) is a particularly severe form of schizophrenia, with an onset during a key time period for both cerebral pruning and myelination.
methodsDiffusion tensor images were acquired from 18 children and adolescents with COS and 25 controls. The COS group was divided into two sub-groups-one with linguistic impairment (LI) and the other without (NLI). The fractional anisotropy (FA), axial (AD), and radial diffusivity (RD) data from the two COS sub-groups were compared to each other and to the controls using tract-based spatial statistics (TBSS) analyses, which is a voxel-based method used to identify regions of white matter abnormalities.
resultsTBSS identified several regions in the left hemisphere where the LI group had increased AD and RD relative to the NLI and the control groups. These areas primarily localized to linguistic tracts: left superior longitudinal fasciculus and left inferior longitudinal fasciculus/inferior fronto-occipital fasciculus. Regions of increased RD overlapped regions of increased AD, with the former showing more pronounced effects.
conclusionsStudies of adult-onset schizophrenia typically identify areas of higher RD but unchanged AD; however, normal development studies have shown that while RD decreases are pronounced over this age range, smaller decreases in AD can also be detected. The observed increases in both RD and AD suggest that developmental disturbances affecting the structural connectivity of these pathways are more severe in COS accompanied by severe linguistic impairments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.