ArticleNeuron2012
Linking the computational structure of variance adaptation to biophysical mechanisms.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Temporal pattern recognition in retinal ganglion cells is mediated by dynamical inhibitory synapses.Nature communications · 2024Article
- Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits.Nature communications · 2022Article
- Predicting and Manipulating Cone Responses to Naturalistic Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency.Cell reports · 2022Article
- A theoretical model reveals specialized synaptic depressions and temporal frequency tuning in retinal parallel channels.Frontiers in computational neuroscience · 2022Article
- Enhancing the dark side: asymmetric gain of cone photoreceptors underpins their discrimination of visual scenes based on skewness.The Journal of physiology · 2022Article
- Efficient and adaptive sensory codes.Nature neuroscience · 2021Article
- Matching visual induction effects on screens of different size.Journal of vision · 2021Article
- Nonlinear spatial integration in retinal bipolar cells shapes the encoding of artificial and natural stimuli.Neuron · 2021Article
- Nonlinear effects of intrinsic dynamics on temporal encoding in a model of avian auditory cortex.PLoS computational biology · 2021Article
- High Contrast Allows the Retina to Compute More Than Just Contrast.Frontiers in cellular neuroscience · 2020Article
- Article
- Multiple Timescales Account for Adaptive Responses across Sensory Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Predicting neuronal dynamics with a delayed gain control model.PLoS computational biology · 2019Article
- Adaptation of Inhibition Mediates Retinal Sensitization.Current biology : CB · 2019Article
- Functional characterization of retinal ganglion cells using tailored nonlinear modeling.Scientific reports · 2019Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
In multiple sensory systems, adaptation to the variance of a sensory input changes the sensitivity, kinetics, and average response over timescales ranging from < 100 ms to tens of seconds. Here, we present a simple, biophysically relevant model of retinal contrast adaptation that accurately captures both the membrane potential response and all adaptive properties. The adaptive component of this model is a first-order kinetic process of the type used to describe ion channel gating and synaptic transmission. From the model, we conclude that all adaptive dynamics can be accounted for by depletion of a signaling mechanism, and that variance adaptation can be explained as adaptation to the mean of a rectified signal. The model parameters show strong similarity to known properties of bipolar cell synaptic vesicle pools. Diverse types of adaptive properties that implement theoretical principles of efficient coding can be generated by a single type of molecule or synapse with just a few microscopic states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.