ArticleCellular microbiology2012
Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan.
Article in Cellular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- U-73122, a phospholipase C inhibitor, impairs lymphocytic choriomeningitis virus virion infectivity.The Journal of general virology · 2024Article
- Lassa Virus Genetics.Current topics in microbiology and immunology · 2023Article
- Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication.Viruses · 2022Article
- Lassa Fever Virus Binds Matriglycan-A Polymer of Alternating Xylose and Glucuronate-On α-Dystroglycan.Viruses · 2021Review
- BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis.PLoS pathogens · 2020Article
- Article
- The function annotations of ST3GAL4 in human LAMP1 and Lassa virus GP-C interaction from the perspective of systems virology.Access microbiology · 2020Article
- TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus.Journal of virology · 2018Article
- Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan.Journal of virology · 2018Article
- Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction.Journal of virology · 2017Review
- Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.Journal of virology · 2016Article
- Dasatinib as a treatment for Duchenne muscular dystrophy.Human molecular genetics · 2016Article
- Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy.Skeletal muscle · 2016Article
- Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man.Future virology · 2015Article
- Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections.The Journal of general virology · 2014Review
- Role of DC-SIGN in Lassa virus entry into human dendritic cells.Journal of virology · 2013Article
- Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan.Cellular microbiology · 2013Article
- Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever.Antiviral research · 2013Review
- The search for animal models for Lassa fever vaccine development.Expert review of vaccines · 2013Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The arenavirus Lassa virus (LASV) causes a severe haemorrhagic fever with high mortality in man. The cellular receptor for LASV is dystroglycan (DG). DG is a ubiquitous receptor for extracellular matrix (ECM) proteins, which cooperates with β1 integrins to control cell-matrix interactions. Here, we investigated whether LASV binding to DG triggers signal transduction, mimicking the natural ligands. Engagement of DG by LASV resulted in the recruitment of the adaptor protein Grb2 and the protein kinase MEK1 by the cytoplasmic domain of DG without activating the MEK/ERK pathway, indicating assembly of an inactive signalling complex. LASV binding to cells however affected the activation of the MEK/ERK pathway via α6β1 integrins. The virus-induced perturbation of α6β1 integrin signalling critically depended on high-affinity LASV binding to DG and DG's cytoplasmic domain, indicating that LASV-receptor binding perturbed signalling cross-talk between DG and β1 integrins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.