ArticleBMC musculoskeletal disorders2012
Ultrasonic reflection coefficient and surface roughness index of OA articular cartilage: relation to pathological assessment.
Article in BMC musculoskeletal disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Realistic Ultrasound Simulations of Healthy and Osteoarthritic Cartilage.Journal of imaging · 2026Article
- Ultra depth of field microscopy: a novel method for observing and characterizing of articular cartilage surface.Journal of translational medicine · 2026Article
- Quantitative ultrasound classification of healthy and chemically degraded ex-vivo cartilage.Scientific reports · 2025Article
- Ultrasound Imaging in Knee Osteoarthritis: Current Role, Recent Advancements, and Future Perspectives.Journal of clinical medicine · 2024Review
- Research progress of ultrasound in accurate evaluation of cartilage injury in osteoarthritis.Frontiers in endocrinology · 2024Review
- Ultrasonographic Evaluation of the Distal Femoral Cartilage Thickness in Parkinson's Patients.Journal of musculoskeletal & neuronal interactions · 2023Article
- Articular surface integrity assessed by ultrasound is associated with biological characteristics of articular cartilage in early-stage degeneration.Scientific reports · 2022Article
- Ultrasound-Based Quantification of Cartilage Damage AfterCartilage · 2021Article
- Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle.PloS one · 2021Article
- Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis.Scientific reports · 2020Article
- Nondestructive Techniques to Evaluate the Characteristics and Development of Engineered Cartilage.Annals of biomedical engineering · 2016Review
- Observation of sGAG content of human hip joint cartilage in different old age groups based on EPIC micro-CT.Connective tissue research · 2015Article
- The Effect of Intra-articular versus Intravenous Injection of Mesenchymal Stem Cells on Experimentally-Induced Knee Joint Osteoarthritis.Journal of microscopy and ultrastructureArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly diagnosis of osteoarthritis (OA) is essential for preventing further cartilage destruction and decreasing severe complications. The aims of this study are to explore the relationship between OA pathological grades and quantitative acoustic parameters and to provide more objective criteria for ultrasonic microscopic evaluation of the OA cartilage.
methodsArticular cartilage samples were prepared from rabbit knees and scanned using ultrasound biomicroscopy (UBM). Three quantitative parameters, including the roughness index of the cartilage surface (URI), the reflection coefficients from the cartilage surface (R) and from the cartilage-bone interface (Rbone) were extracted. The osteoarthritis grades of these cartilage samples were qualitatively assessed by histology according to the grading standards of International Osteoarthritis Institute (OARSI). The relationship between these quantitative parameters and the osteoarthritis grades was explored.
resultsThe results showed that URI increased with the OA grade. URI of the normal cartilage samples was significantly lower than the one of the OA cartilage samples. There was no significant difference in URI between the grade 1 cartilage samples and the grade 2 cartilage samples. The reflection coefficient of the cartilage surface reduced significantly with the development of OA (p < 0.05), while the reflection coefficient of the cartilage-bone interface increased with the increase of grade.
conclusionHigh frequency ultrasound measurements can reflect the changes in the surface roughness index and the ultrasound reflection coefficients of the cartilage samples with different OA grades. This study may provide useful information for the quantitative ultrasonic diagnosis of early OA.
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