ArticleStructure (London, England : 1993)2012
Variable lymphocyte receptor recognition of the immunodominant glycoprotein of Bacillus anthracis spores.
Article in Structure (London, England : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Phage Display Reveals VLRB-Mediated Recognition of Minimal Tumor Glycan Antigen Sialyl-Tn.Current issues in molecular biology · 2025Article
- Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells.Nature communications · 2025Article
- Article
- Lamprey Variable Lymphocyte Receptor Monoclonal Antibodies for Whole-Cell Surface Antigens.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Identification of Glycan-Specific Variable Lymphocyte Receptors Using Yeast Surface Display and Glycan Microarrays.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system.Immunogenetics · 2021Review
- Development of smart anti-glycan reagents using immunized lampreys.Communications biology · 2020Article
- Characterization of Hagfish (Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells.Science advances · 2018Article
- The variable lymphocyte receptor as an antibody alternative.Current opinion in biotechnology · 2018Review
- Globular-shaped variable lymphocyte receptors B antibody multimerized by a hydrophobic clustering in hagfish.Scientific reports · 2018Article
- VLR Recognition of TLR5 Expands the Molecular Characterization of Protein Antigen Binding by Non-Ig-based Antibodies.Journal of molecular biology · 2018Article
- Crystal structure of an anti-idiotype variable lymphocyte receptor.Acta crystallographica. Section F, Structural biology communications · 2017Article
- Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates.Structure (London, England : 1993) · 2017Article
- Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans.Molecular and cellular biology · 2017Article
- Leucine-rich-repeat-containing variable lymphocyte receptors as modules to target plant-expressed proteins.Plant methods · 2017Article
- Identification and characterisation of the immune response properties of Lampetra japonica BLNK.Scientific reports · 2016Article
- Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae.Scientific reports · 2016Article
- Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors.Molecular therapy oncolytics · 2016Article
- Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity.eLife · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Variable lymphocyte receptors (VLRs) are the adaptive immune receptors of jawless fish, which evolved adaptive immunity independent of other vertebrates. In lieu of the immunoglobulin fold-based T and B cell receptors, lymphocyte-like cells of jawless fish express VLRs (VLRA, VLRB, or VLRC) composed of leucine-rich repeats and are similar to toll-like receptors (TLRs) in structure, but antibodies (VLRB) and T cell receptors (VLRA and VLRC) in function. Here, we present the structural and biochemical characterization of VLR4, a VLRB, in complex with BclA, the immunodominant glycoprotein of Bacillus anthracis spores. Using a combination of crystallography, mutagenesis, and binding studies, we delineate the mode of antigen recognition and binding between VLR4 and BclA, examine commonalities in VLRB recognition of antigens, and demonstrate the potential of VLR4 as a diagnostic tool for the identification of B. anthracis spores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.