ArticleBiophysical journal2012
Membrane clustering and the role of rebinding in biochemical signaling.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
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- Lifetime of actin-dependent protein nanoclusters.Biophysical journal · 2023Article
- Optimal ligand discrimination by asymmetric dimerization and turnover of interferon receptors.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular Crowding and Diffusion-Capture in Synapses.iScience · 2020Article
- Development of a Simple Kinetic Mathematical Model of Aggregation of Particles or Clustering of Receptors.Life (Basel, Switzerland) · 2020Article
- Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation.Science advances · 2020Article
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- DrLLPS: a data resource of liquid-liquid phase separation in eukaryotes.Nucleic acids research · 2020Article
- Ligand Density and Nanoparticle Clustering Cooperate in the Multivalent Amplification of Epidermal Growth Factor Receptor Activation.ACS nano · 2018Article
- Unified path integral approach to theories of diffusion-influenced reactions.Physical review. E · 2017Article
- 3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse.Scientific reports · 2017Article
- Cooperative Clustering Digitizes Biochemical Signaling and Enhances its Fidelity.Biophysical journal · 2016Article
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- Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.Membranes · 2015Review
- Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.PLoS computational biology · 2015Article
- The robustness of proofreading to crowding-induced pseudo-processivity in the MAPK pathway.Biophysical journal · 2014Article
- Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model.BMC systems biology · 2014Article
- Biosensor architectures for high-fidelity reporting of cellular signaling.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many cellular signaling pathways, key components form clusters at the cell membrane. Although much work has focused on the mechanisms behind such cluster formation, the implications for downstream signaling remain poorly understood. Here, motivated by recent experiments, we use particle-based simulation to study a covalent modification network in which the activating component is either clustered or randomly distributed on the membrane. We find that whereas clustering reduces the response of a single-modification network, it can enhance the response of a double-modification network. The reduction is a bulk effect: a cluster presents a smaller effective target to a substrate molecule in the bulk. The enhancement, on the other hand, is a local effect: a cluster promotes the rapid rebinding and second activation of singly activated substrate molecules. As such, the enhancement relies on frequent collisions on a short timescale, leading to an optimal ratio of diffusion to association that agrees with typical measured rates. We complement simulation with analytic results at both the mean-field and first-passage distribution levels. Our results emphasize the importance of spatially resolved models, showing that significant effects of spatial correlations persist even in spatially averaged quantities such as response curves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.