ArticleActa obstetricia et gynecologica Scandinavica2012
Maternal lipids at mid-pregnancy and the risk of preterm delivery.
Article in Acta obstetricia et gynecologica Scandinavica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- The effect of statins exposure during pregnancy on congenital anomalies and spontaneous abortions: A systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2018Pooled it
- Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review.Archives of gynecology and obstetrics · 2017Pooled it
- Maternal plasma lipid levels across pregnancy and the risks of small-for-gestational age and low birth weight: a cohort study from rural Gambia.BMC pregnancy and childbirth · 2020Trial
- Influence of aerobic exercise on maternal lipid levels and offspring morphometrics.International journal of obesity (2005) · 2019Trial
- Exercise during pregnancy on maternal lipids: a secondary analysis of randomized controlled trial.BMC pregnancy and childbirth · 2017Trial
- Maternal plasma cholesterol and duration of pregnancy: A prospective cohort study in Ghana.Maternal & child nutrition · 2017Trial
- Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials.Prostaglandins, leukotrienes, and essential fatty acids · 2017Trial
- Impacts of maternal lipid and homocysteine levels on the risks of pregnancy complications and adverse outcomes in both singleton and twin pregnancies: a population-based observational cohort study.BMC pregnancy and childbirth · 2026Observational
- Trajectories of and trimester-specific six maternal lipid indices during pregnancy associated with preterm birth and its subtypes: a cohort-based record-linkage study.BMC pregnancy and childbirth · 2026Article
- Pregnancy and neonatal outcomes following statin exposure in early pregnancy: a nationwide consultation-based cohort study in Japan.BMC pregnancy and childbirth · 2026Article
- The Effect of a Supervised Exercise Program Throughout Pregnancy on Longitudinal Lipid Profile Changes: A Randomized Clinical Trial.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Maternal dyslipidemia in the first trimester and adverse pregnancy and offspring outcomes: based on the Tianjin birth cohort.Lipids in health and disease · 2025Article
- Maternal Dyslipidemia and Its Association With Preterm Birth and Other Adverse Perinatal Outcomes.Cureus · 2025Article
- Maternal Lipids in Pregnancy and Later Life Dyslipidemia: The POUCHmoms Longitudinal Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Gestational diabetes complicated with preterm birth: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- The association between dyslipidaemia in the first trimester and adverse pregnancy outcomes in pregnant women with subclinical hypothyroidism: a cohort study.Lipids in health and disease · 2024Article
- Evaluation of hyper-lipidaemia as a predictive marker for gestational diabetes among Indian women.Bioinformation · 2024Article
- Association between second- and third-trimester maternal lipid profiles and adverse perinatal outcomes among women with GDM and non-GDM: a retrospective cohort study.BMC pregnancy and childbirth · 2023Article
- Diagnosing Arterial Stiffness in Pregnancy and Its Implications in the Cardio-Renal-Metabolic Chain.Diagnostics (Basel, Switzerland) · 2022Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThis study examined associations between maternal lipid levels at mid-pregnancy and preterm delivery, medically indicated or spontaneous.
designProspective cohort study.
settingWomen were recruited from 52 clinics in five Michigan, USA communities (1998-2004). POPULATION: Pregnant women were enrolled at 15-27 weeks' gestation and followed to delivery (n=3019).
methodsA single blood sample was obtained at study enrollment. Blood lipids, i.e. total cholesterol (TC), high-density lipoprotein (HDLc), low-density lipoprotein (LDLc) cholesterol, and triglycerides (TG), were measured on a sub-cohort (n=1309).
main outcome measuresThere were 221 spontaneous, 100 medically indicated preterm deliveries and 988 term deliveries. Polytomous logistic regression models examined relationships among cholesterol levels (Low: <10(th) percentile, Referent: 10(th) -<70(th) percentile, High: ≥70(th) percentile), quartiles of TG (Referent: first quartile) and delivery outcome (Referent: term).
resultsOdds of medically indicated preterm delivery were increased among women with low TC (adjusted odds ratio (aOR)=2.04, 95% confidence interval (CI): 1.12, 3.72), low HDLc (aOR=1.89, 95%CI: 1.04, 3.42) or low LDLc (aOR=1.96, 95%CI: 1.09, 3.54). Odds of spontaneous preterm delivery were increased among women with high TC (aOR=1.51, 95%CI: 1.06, 2.15), high LDLc (aOR=1.42, 95%CI: 0.99, 2.04) or high TG (aOR=1.90, 95%CI: 1.21, 2.97 and aOR=1.72, 95%CI: 1.06, 2.78 for third and fourth quartiles, respectively).
conclusionsExtremely low TC, HDLc, and LDLc were associated with a modest increase in risk of medically indicated preterm delivery, whereas high TC, LDLc and TG modestly increased the risk of spontaneous preterm delivery. Further research is needed to uncover explanations for these associations and to identify optimal ranges for maternal lipids.
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