ArticleBritish journal of pharmacology2012
MDMA and 5-HT neurotoxicity: the empirical evidence for its adverse effects in humans - no need for translation.
Article in British journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Effects of acute MDMA intoxication on mood and impulsivity: role of the 5-HT2 and 5-HT1 receptors.PloS one · 2012Trial
- Serotonin toxicity of serotonergic psychedelics.Psychopharmacology · 2022Review
- Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats.International journal of molecular sciences · 2019Article
- Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage.Neurotoxicity research · 2017Article
- Acute effects of the designer drugs benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) using functional magnetic resonance imaging (fMRI) and the Stroop task--a pilot study.Psychopharmacology · 2015Article
- Legal highs: staying on top of the flood of novel psychoactive substances.Therapeutic advances in psychopharmacology · 2015Review
- Mechanisms and environmental factors that underlying the intensification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced serotonin syndrome in rats.Psychopharmacology · 2015Article
- MDMA modulates spontaneous firing of subthalamic nucleus neurons in vitro.Experimental brain research · 2015Article
- MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex.Psychopharmacology · 2014Article
- Alterations to global but not local motion processing in long-term ecstasy (MDMA) users.Psychopharmacology · 2014Article
- The preclinical pharmacology of mephedrone; not just MDMA by another name.British journal of pharmacology · 2014Review
- MDMA and heightened cortisol: a neurohormonal perspective on the pregnancy outcomes of mothers used 'Ecstasy' during pregnancy.Human psychopharmacology · 2014Review
- Psychiatric profiles of mothers who take Ecstasy/MDMA during pregnancy: reduced depression 1 year after giving birth and quitting Ecstasy.Journal of psychopharmacology (Oxford, England) · 2014Observational
- Saturday night fever in ecstasy/MDMA dance clubbers: Heightened body temperature and associated psychobiological changes.Temperature (Austin, Tex.)Article
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of the BJP, Green et al. suggest that animal data could not be used to predict the adverse effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans and that MDMA did not produce 5-HT neurotoxicity in the human brain. This proposal was, however, not accompanied by a review of the empirical evidence in humans. The neuroimaging data on 5-HT markers in abstinent recreational ecstasy/MDMA users are extensive and broadly consistent. Reduced levels of the 5-HT transporter (SERT) have been found by research groups worldwide using a variety of assessment measures. These SERT reductions occur across the higher brain regions and remain after controlling for potential confounds. There are also extensive empirical data for impairments in memory and higher cognition, with the neurocognitive deficits correlating with the extent of SERT loss. Hence, MDMA is clearly damaging to humans, with extensive empirical data for both structural and functional deficits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.