ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2012
The role of the superior laryngeal nerve in esophageal reflexes.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Elicitation of the Swallowing Reflex by Esophageal Stimulation in Healthy Subjects: An Evaluation Using High-Resolution Manometry.Dysphagia · 2020Trial
- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Coordination of Pharyngeal and Esophageal Phases of Swallowing.Journal of neurogastroenterology and motility · 2024Review
- Anesthetic management of airway stent placement by rigid bronchoscopy with superior laryngeal nerve block while preserving spontaneous breathing: A case report.Clinical case reports · 2023Article
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Ultrasound-Guided Block of the Internal Branch of the Superior Laryngeal Nerve Reduces Postoperative Sore Throat Caused by Suspension Laryngoscopic Surgery: A Prospective Randomized Trial.Frontiers in surgery · 2022Article
- Article
- Author's reply: Laryngopharyngeal reflux as a potential cause of persistent local neck symptoms after total thyroidectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Effects of esophageal acidification on esophageal reflexes controlling the upper esophageal sphincter.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Animal Models for Dysphagia Studies: What Have We Learnt So Far.Dysphagia · 2017Review
- Characterization and mechanisms of the pharyngeal swallow activated by stimulation of the esophagus.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- The Physiology of Eructation.Dysphagia · 2016Review
- How uncomplicated total thyroidectomy could aggravate the laryngopharyngeal reflux disease?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Mechanism of UES relaxation initiated by gastric air distension.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Respiratory events in infants presenting with apparent life threatening events: is there an explanation from esophageal motility?The Journal of pediatrics · 2014Article
- Esophageal reflexes modulate frontoparietal response in neonates: Novel application of concurrent NIRS and provocative esophageal manometry.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Role of peripheral reflexes in the initiation of the esophageal phase of swallowing.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Laryngeal and tracheal afferent nerve stimulation evokes swallowing in anaesthetized guinea pigs.The Journal of physiology · 2013Article
- Digestive and respiratory tract motor responses associated with eructation.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to determine the role of the superior laryngeal nerve (SLN) in the following esophageal reflexes: esophago-upper esophageal sphincter (UES) contractile reflex (EUCR), esophago-lower esophageal sphincter (LES) relaxation reflex (ELIR), secondary peristalsis, pharyngeal swallowing, and belch. Cats (N = 43) were decerebrated and instrumented to record EMG of the cricopharyngeus, thyrohyoideus, geniohyoideus, and cricothyroideus; esophageal pressure; and motility of LES. Reflexes were activated by stimulation of the esophagus via slow balloon or rapid air distension at 1 to 16 cm distal to the UES. Slow balloon distension consistently activated EUCR and ELIR from all areas of the esophagus, but the distal esophagus was more sensitive than the proximal esophagus. Transection of SLN or proximal recurrent laryngeal nerves (RLN) blocked EUCR and ELIR generated from the cervical esophagus. Distal RLN transection blocked EUCR from the distal cervical esophagus. Slow distension of all areas of the esophagus except the most proximal few centimeters activated secondary peristalsis, and SLN transection had no effect on secondary peristalsis. Slow distension of all areas of the esophagus inconsistently activated pharyngeal swallows, and SLN transection blocked generation of pharyngeal swallows from all levels of the esophagus. Slow distension of the esophagus inconsistently activated belching, but rapid air distension consistently activated belching from all areas of the esophagus. SLN transection did not block initiation of belch but blocked one aspect of belch, i.e., inhibition of cricopharyngeus EMG. Vagotomy blocked all aspects of belch generated from all areas of esophagus and blocked all responses of all reflexes not blocked by SLN or RLN transection. In conclusion, the SLN mediates all aspects of the pharyngeal swallow, no portion of the secondary peristalsis, and the EUCR and ELIR generated from the proximal esophagus. Considering that SLN is not a motor nerve for any of these reflexes, the role of the SLN in control of these reflexes is sensory in nature only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.