ArticlePloS one2012
Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression.Histochemistry and cell biology · 2023Article
- Norepinephrine and Vasopressin in Hemorrhagic Shock: A Focus on Renal Hemodynamics.International journal of molecular sciences · 2023Review
- Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response.Aging and disease · 2022Article
- Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function.Frontiers in immunology · 2022Article
- Effects of Lipoic Acid on Ischemia-Reperfusion Injury.Oxidative medicine and cellular longevity · 2021Review
- Effects of Connexin 32-Mediated Lung Inflammation Resolution During Liver Ischemia Reperfusion.Digestive diseases and sciences · 2020Article
- The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock.Shock (Augusta, Ga.) · 2019Article
- The Protective Effect of Magnesium Lithospermate B on Hepatic Ischemia/ReperfusionFrontiers in pharmacology · 2019Article
- Evaluation of capillary leakage after vasopressin resuscitation in a hemorrhagic shock model.World journal of emergency surgery : WJES · 2018Article
- Hypoxemic reperfusion of ischemic states: an alternative approach for the attenuation of oxidative stress mediated reperfusion injury.Journal of biomedical science · 2016Review
- Global consequences of liver ischemia/reperfusion injury.Oxidative medicine and cellular longevity · 2014Review
- Superimposed traumatic brain injury modulates vasomotor responses in third-order vessels after hemorrhagic shock.Scandinavian journal of trauma, resuscitation and emergency medicine · 2013Article
- Does vasopressor therapy have an indication in hemorrhagic shock?Annals of intensive care · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHemorrhagic shock and resuscitation is frequently associated with liver ischemia-reperfusion injury. The aim of the study was to investigate whether hypoxemic resuscitation attenuates liver injury.
methodsAnesthetized, mechanically ventilated New Zealand white rabbits were exsanguinated to a mean arterial pressure of 30 mmHg for 60 minutes. Resuscitation under normoxemia (Normox-Res group, n = 16, PaO(2) = 95-105 mmHg) or hypoxemia (Hypox-Res group, n = 15, PaO(2) = 35-40 mmHg) followed, modifying the FiO(2). Animals not subjected to shock constituted the sham group (n = 11, PaO(2) = 95-105 mmHg). Indices of the inflammatory, oxidative and nitrosative response were measured and histopathological and immunohistochemical studies of the liver were performed.
resultsNormox-Res group animals exhibited increased serum alanine aminotransferase, tumor necrosis factor--alpha, interleukin (IL) -1β and IL-6 levels compared with Hypox-Res and sham groups. Reactive oxygen species generation, malondialdehyde formation and myeloperoxidase activity were all elevated in Normox-Res rabbits compared with Hypox-Res and sham groups. Similarly, endothelial NO synthase and inducible NO synthase mRNA expression was up-regulated and nitrotyrosine immunostaining increased in animals resuscitated normoxemically, indicating a more intense nitrosative stress. Hypox-Res animals demonstrated a less prominent histopathologic injury which was similar to sham animals.
conclusionsHypoxemic resuscitation prevents liver reperfusion injury through attenuation of the inflammatory response and oxidative and nitrosative stresses.
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