ArticlePloS one2012
Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- TNF-α Deficiency Reduces Parvalbumin Neuron Density, Impairs Homeostatic Plasticity, Disrupts Synaptic Excitation-Inhibition Balance, and Prevents Critical Period Closure in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation.Frontiers in molecular neuroscience · 2026Article
- Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures.Scientific reports · 2025Article
- Waveform-based classification of dentate spikes.Scientific reports · 2024Article
- Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses.Cells · 2024Article
- Time-lapse imaging of identified granule cells in the mouse dentate gyrus after entorhinal lesionFrontiers in neuroanatomy · 2024Article
- Waveform-based classification of dentate spikes.bioRxiv : the preprint server for biology · 2023Article
- The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Heterogeneous CaMKII-Dependent Synaptic Compensations in CA1 Pyramidal Neurons From Acute Hippocampal Slices.Frontiers in cellular neuroscience · 2022Article
- Article
- Amyloid-Beta Mediates Homeostatic Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- EphrinB2 and GRIP1 stabilize mushroom spines during denervation-induced homeostatic plasticity.Cell reports · 2021Article
- Maturation-Dependent Differences in the Re-innervation of the Denervated Dentate Gyrus by Sprouting Associational and Commissural Mossy Cell Axons in Organotypic Tissue Cultures of Entorhinal Cortex and Hippocampus.Frontiers in neuroanatomy · 2021Article
- TNF-Mediated Homeostatic Synaptic Plasticity: FromFrontiers in cellular neuroscience · 2020Review
- Interleukin 10 Restores Lipopolysaccharide-Induced Alterations in Synaptic Plasticity Probed by Repetitive Magnetic Stimulation.Frontiers in immunology · 2020Article
- Re-innervation of the Denervated Dentate Gyrus by Sprouting Associational and Commissural Mossy Cell Axons in Organotypic Tissue Cultures of Entorhinal Cortex and Hippocampus.Frontiers in molecular neuroscience · 2019Article
- Removal of area CA3 from hippocampal slices induces postsynaptic plasticity at Schaffer collateral synapses that normalizes CA1 pyramidal cell discharge.Neuroscience letters · 2018Article
- Dopamine Modulates Homeostatic Excitatory Synaptic Plasticity of Immature Dentate Granule Cells in Entorhino-Hippocampal Slice Cultures.Frontiers in molecular neuroscience · 2018Article
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6 authors.
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Abstract
Denervation-induced changes in excitatory synaptic strength were studied following entorhinal deafferentation of hippocampal granule cells in mature (≥ 3 weeks old) mouse organotypic entorhino-hippocampal slice cultures. Whole-cell patch-clamp recordings revealed an increase in excitatory synaptic strength in response to denervation during the first week after denervation. By the end of the second week synaptic strength had returned to baseline. Because these adaptations occurred in response to the loss of excitatory afferents, they appeared to be in line with a homeostatic adjustment of excitatory synaptic strength. To test whether denervation-induced changes in synaptic strength exploit similar mechanisms as homeostatic synaptic scaling following pharmacological activity blockade, we treated denervated cultures at 2 days post lesion for 2 days with tetrodotoxin. In these cultures, the effects of denervation and activity blockade were not additive, suggesting that similar mechanisms are involved. Finally, we investigated whether entorhinal denervation, which removes afferents from the distal dendrites of granule cells while leaving the associational afferents to the proximal dendrites of granule cells intact, results in a global or a local up-scaling of granule cell synapses. By using computational modeling and local electrical stimulations in Strontium (Sr(2+))-containing bath solution, we found evidence for a lamina-specific increase in excitatory synaptic strength in the denervated outer molecular layer at 3-4 days post lesion. Taken together, our data show that entorhinal denervation results in homeostatic functional changes of excitatory postsynapses of denervated dentate granule cells in vitro.
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