ArticlePloS one2012
Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- An HWE-Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response.Molecular microbiology · 2025Article
- Identifying immunoreactive proteins in brucellin for enhanced brucellosis diagnosis: a proteomic approach.Frontiers in microbiology · 2025Article
- Scanning iron response regulator binding sites using Dap-seq in the Brucella genome.PLoS neglected tropical diseases · 2023Article
- Uncovering the Hidden Credentials ofMicrobiology and molecular biology reviews : MMBR · 2021Review
- When the Going Gets Rough: The Significance ofFrontiers in microbiology · 2021Review
- Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis.BMC molecular biology · 2018Article
- Variability in the response of canine and human dendritic cells stimulated with Brucella canis.Veterinary research · 2017Article
- Iron-dependent reconfiguration of the proteome underlies the intracellular lifestyle of Brucella abortus.Scientific reports · 2017Article
- Relative Quantitative Proteomic Analysis ofFrontiers in microbiology · 2017Article
- The Bacterial Second Messenger Cyclic di-GMP Regulates Brucella Pathogenesis and Leads to Altered Host Immune Response.Infection and immunity · 2016Article
- Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts.Infection and immunity · 2015Article
- Erythritol triggers expression of virulence traits in Brucella melitensis.Microbes and infection · 2013Article
- Comparative genomic analysis of Brucella melitensis vaccine strain M5 provides insights into virulence attenuation.PloS one · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Brucella spp. cause chronic zoonotic disease often affecting individuals and animals in impoverished economic or public health conditions; however, these bacteria do not have obvious virulence factors. Restriction of iron availability to pathogens is an effective strategy of host defense. For brucellae, virulence depends on the ability to survive and replicate within the host cell where iron is an essential nutrient for the growth and survival of both mammalian and bacterial cells. Iron is a particularly scarce nutrient for bacteria with an intracellular lifestyle. Brucella melitensis and Brucella canis share ~99% of their genomes but differ in intracellular lifestyles. To identify differences, gene transcription of these two pathogens was examined during infection of murine macrophages and compared to broth grown bacteria. Transcriptome analysis of B. melitensis and B. canis revealed differences of genes involved in iron transport. Gene transcription of the TonB, enterobactin, and ferric anguibactin transport systems was increased in B. canis but not B. melitensis during infection of macrophages. The data suggest differences in iron requirements that may contribute to differences observed in the lifestyles of these closely related pathogens. The initial importance of iron for B. canis but not for B. melitensis helps elucidate differing intracellular survival strategies for two closely related bacteria and provides insight for controlling these pathogens.
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Registered trials
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